Document Detail

The effect of sublethal lead exposure on the ultrastructure and on the distribution of acid phosphatase activity in chloragocytes of earthworms (Annelida, Oligochaeta).
MedLine Citation:
PMID:  8789397     Owner:  NLM     Status:  MEDLINE    
Laboratory experiments were conducted to study the effects of the exposure to a sublethal concentration (500 p.p.m.) of lead on the ultrastructure and acid phosphatase compartmentalization of the chloragogenous tissue of earthworms, Eisenia foetida. For the cytochemical demonstration of acid phosphatase activity, lead and cerium were used as capturing agents. In both cases there was a change in the compartmentalization of acid phosphatase, the enzyme activity being localized within the chloragosomes in controls, but distributed throughout the cytosol in treated animals. In addition, acid phosphatase activity increased following lead exposure. At the ultrastructural level, disruption of the chloragosomal membranes, an increase in chloragosomal fusion processes and vesiculation of the cytoplasm were evident. Moreover, an enhanced release of chloragosomes to the extracellular space was found in lead-exposed worms.
I Cancio; I Gwynn; M P Ireland; M P Cajaraville
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Histochemical journal     Volume:  27     ISSN:  0018-2214     ISO Abbreviation:  Histochem. J.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0163161     Medline TA:  Histochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  965-73     Citation Subset:  IM    
Electron Microscopy Unit, Institute of Biological Sciences, University of Wales, Aberystwyth, UK.
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MeSH Terms
Acid Phosphatase / metabolism*
Cytosol / enzymology,  metabolism,  ultrastructure
Digestive System / drug effects,  metabolism*,  ultrastructure
Lead / metabolism,  toxicity*
Membranes / drug effects,  enzymology
Microscopy, Electron
Oligochaeta / physiology*
Subcellular Fractions / drug effects,  metabolism,  ultrastructure
Reg. No./Substance:
7439-92-1/Lead; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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