Document Detail

The effect of subclinical ketosis in early lactation on reproductive performance of postpartum dairy cows.
MedLine Citation:
PMID:  17517719     Owner:  NLM     Status:  MEDLINE    
Data generated from 796 Holstein cows enrolled in a clinical trial to investigate the health effect of a monensin controlled release capsule were analyzed to investigate the association between circulating serum beta-hydroxybutyrate (BHBA) concentration in the peri-parturient period and subsequent reproductive performance. Overall, accounting for both repeated measures within cow and clustering at the herd level, non-pregnant cows after first insemination tended to have increased circulating BHBA concentrations from 3 wk before calving to 9 wk after calving relative to pregnant cows. Including the interaction between the week of sample collection and pregnancy outcome, non-pregnant cows had higher circulating BHBA concentrations in the second week after calving than cows diagnosed pregnant after first artificial insemination. Within individual weeks, cows with circulating BHBA concentrations > or =1,000 micromol/L in the first week postpartum were less likely to be diagnosed pregnant after first insemination. In the second week postpartum, the cows with circulating BHBA concentrations > or =1,400 micromol/L were significantly less likely to be pregnant after first artificial insemination. A dose response relationship was found when a comparison of the probability of pregnancy after first insemination and duration of elevated circulating ketone bodies was investigated. The probability of pregnancy was reduced by 20% in cows diagnosed subclinically ketotic in either the first or second week postpartum. Nevertheless, cows above the subclinical ketosis threshold in both the first and second week postpartum were 50% less likely to be pregnant after first insemination. Similarly, the median time to pregnancy increased in cows experiencing elevated BHBA concentrations in either (124 d) or both (130 d) the first and second week postpartum relative to cows never experiencing elevated BHBA concentrations (108 d). To further investigate this, the effect of elevated circulating BHBA was permitted to vary with time. The effect decreased with time, such that the daily probability of pregnancy increased similar to nonsubclinically ketotic cows by approximately 160 d in milk. From this analysis, both the relative circulating concentration of BHBA and the duration of elevated circulating BHBA were negatively associated with the probability of pregnancy at first service.
R B Walsh; J S Walton; D F Kelton; S J LeBlanc; K E Leslie; T F Duffield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dairy science     Volume:  90     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-22     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2788-96     Citation Subset:  IM    
Department of Population Medicine, University of Guelph, Ontario, Canada, N1G 2W1.
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MeSH Terms
3-Hydroxybutyric Acid / blood*
Cattle Diseases / blood*
Cluster Analysis
Delayed-Action Preparations
Insemination, Artificial / veterinary
Ionophores / administration & dosage
Ketosis / blood,  complications,  veterinary*
Lactation / blood*,  metabolism,  physiology
Monensin / administration & dosage
Postpartum Period / blood
Pregnancy Outcome / veterinary
Pregnancy Rate
Pregnancy, Animal / blood*
Reproduction / physiology*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Ionophores; 17090-79-8/Monensin; 300-85-6/3-Hydroxybutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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