| The effect of stress hormones on cerebral hemodynamics in patients with chronic posttraumatic stress disorder. | |
| | |
MedLine Citation:
|
PMID: 20405635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of the study was to assess the possible correlation between catecholamine and cortisol levels and changes in cerebral hemodynamics in patients with chronic posttraumatic stress disorder (PTSD). The study included 50 patients with chronic PTSD first ever hospitalized for psychiatric treatment and 50 healthy control subjects. All study subjects were aged 30-50. In PTSD patients, 24-h urine levels of the epinephrine and norepinephrine metabolites vanillylmandelic acid (VMA) and cortisol were determined and transcranial Doppler ultrasonography was performed on day 1 of hospital stay and repeated after 21-day psychiatric medicamentous treatment. On initial testing, increased level of 24-h VMA, decreased cortisol level and elevated mean blood flow velocity (MBFV) in the circle of Willis vessels were recorded in 25 (50.00%) patients. Repeat findings obtained after 21-day psychopharmaceutical therapy showed increased 24-h VMA, decreased cortisol and elevated MBFV in the circle of Willis vessels in seven (14.00%) patients (initial vs. repeat testing, P = 0.0002). Such parameters were not recorded in any of the control subjects (initial PTSD patient testing vs. control group, P = 0.0000). Study results pointed to a significant correlation between increased catecholamine levels, decreased cortisol level and elevated MBFV in the circle of Willis vessels caused by cerebral vasospasm. Psychiatric medicamentous therapy administered for three weeks significantly reduced the proportion of patients with concurrently altered cerebral hemodynamics, increased levels of catecholamine metabolites and decreased level of cortisol. |
| | |
Authors:
|
Marinko Dikanovi?; Dragutin Kadoji?; Vida Demarin; Zlatko Trkanjec; Ivan Mihaljevi?; Milan Bitunjac; Mira Kadoji?; Ivo Mati?; Lidija Sapina; Vladimir Vuleti?; Ljiljana Cengi? |
Related Documents
:
|
910805 - Intracranial tumors simulating the presentation of cerebrovascular syndromes. early det... 10402335 - Posterior circulation abnormalities in moyamoya disease : a radiological study. 11599915 - Detection of lipoprotein(a) in intraparenchymal cerebral vessels: correlation with vasc... 20522815 - Spontaneous angiographic conversion of intracranial dural arteriovenous shunt: long-ter... 11242485 - Blood sulfur-amino acid concentration reflects an impairment of liver transsulfuration ... 6279815 - Congenital hypertrophic pyloric stenosis and associated anomalies in the genitourinary ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta clinica Croatica Volume: 48 ISSN: 0353-9466 ISO Abbreviation: Acta Clin Croat Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2010-04-21 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9425483 Medline TA: Acta Clin Croat Country: Croatia |
Other Details:
|
Languages: eng Pagination: 405-11 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Dr. Josip Bencevi? General Hospital, Slavonski Brod, Croatia. idikanov@inet.hr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity Catecholamines / metabolism* Cerebrovascular Circulation* Hemodynamics Humans Hydrocortisone / metabolism* Male Middle Aged Stress Disorders, Post-Traumatic / complications, physiopathology*, ultrasonography Ultrasonography, Doppler, Transcranial Vanilmandelic Acid / metabolism* Vasospasm, Intracranial / complications*, ultrasonography |
| Chemical | |
Reg. No./Substance:
|
0/Catecholamines; 50-23-7/Hydrocortisone; 55-10-7/Vanilmandelic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risk factors and outcome differences between ischemic and hemorrhagic stroke.
Next Document: Thyroid nodularity--true epidemic or improved diagnostics.