Document Detail

The effect of stress on the antioxidative potential of serum: implications for Alzheimer's disease.
MedLine Citation:
PMID:  16770696     Owner:  NLM     Status:  MEDLINE    
There is growing consensus in the literature that oxidation status is increased in Alzheimer's disease (AD), and that antioxidant supplementation as prevention or treatment strategy should be investigated further. In the present study the total antioxidant status (TAS) was found to be highly significantly lower in 22 AD patients (p < 0.0001) than in 22 age- and gender matched non-demented controls. The TAS was also lower than controls in 22 patients with vascular dementia, but not significantly. The increased oxidation status in AD was verified using the benzoate hydroxylation method. The origin of the enhanced oxidation status in AD has not been elucidated. To determine whether a causal effect between stress and oxidative status of serum can be demonstrated, a rat model was used with two different kinds of stressors, swim stress (exercise) and restraint stress (non-exercise stress). Following swim stress the maximum oxidative effect was observed at one hour post stress (p < 0.001). At 24 h the oxidative status had recovered significantly to below control values. Restraint stress, however, showed progressively increased oxidation which attained significance after 24 h (p < 0.005). It is postulated that stress may contribute to the higher oxidation status in AD patients.
S J van Rensburg; J M van Zyl; F C V Potocnik; W M U Daniels; J Uys; L Marais; D Hon; B J van der Walt; R T Erasmus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-13
Journal Detail:
Title:  Metabolic brain disease     Volume:  21     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-9     Citation Subset:  IM    
Department of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital and Stellenbosch University, P.O. Box 19113, 7505 Tygerberg, South Africa.
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MeSH Terms
Alzheimer Disease / blood*
Antioxidants / metabolism*
Benzoic Acid / metabolism
Rats, Sprague-Dawley
Restraint, Physical
Stress, Psychological / metabolism*
Swimming / psychology
Reg. No./Substance:
0/Antioxidants; 65-85-0/Benzoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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