| The effect of stress on the antioxidative potential of serum: implications for Alzheimer's disease. | |
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MedLine Citation:
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PMID: 16770696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is growing consensus in the literature that oxidation status is increased in Alzheimer's disease (AD), and that antioxidant supplementation as prevention or treatment strategy should be investigated further. In the present study the total antioxidant status (TAS) was found to be highly significantly lower in 22 AD patients (p < 0.0001) than in 22 age- and gender matched non-demented controls. The TAS was also lower than controls in 22 patients with vascular dementia, but not significantly. The increased oxidation status in AD was verified using the benzoate hydroxylation method. The origin of the enhanced oxidation status in AD has not been elucidated. To determine whether a causal effect between stress and oxidative status of serum can be demonstrated, a rat model was used with two different kinds of stressors, swim stress (exercise) and restraint stress (non-exercise stress). Following swim stress the maximum oxidative effect was observed at one hour post stress (p < 0.001). At 24 h the oxidative status had recovered significantly to below control values. Restraint stress, however, showed progressively increased oxidation which attained significance after 24 h (p < 0.005). It is postulated that stress may contribute to the higher oxidation status in AD patients. |
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Authors:
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S J van Rensburg; J M van Zyl; F C V Potocnik; W M U Daniels; J Uys; L Marais; D Hon; B J van der Walt; R T Erasmus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-13 |
Journal Detail:
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Title: Metabolic brain disease Volume: 21 ISSN: 0885-7490 ISO Abbreviation: Metab Brain Dis Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-12-15 Completed Date: 2007-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610370 Medline TA: Metab Brain Dis Country: United States |
Other Details:
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Languages: eng Pagination: 171-9 Citation Subset: IM |
Affiliation:
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Department of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital and Stellenbosch University, P.O. Box 19113, 7505 Tygerberg, South Africa. sjvr@sun.ac.za |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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blood* Animals Antioxidants / metabolism* Benzoic Acid / metabolism Hydroxylation Male Rats Rats, Sprague-Dawley Restraint, Physical Stress, Psychological / metabolism* Swimming / psychology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 65-85-0/Benzoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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