Document Detail


The effect of stress on absorption of acetaminophen.
MedLine Citation:
PMID:  16541246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: There is a large variability in the response to pharmacological treatment. Some studies have linked this variability to stress levels, i.e., stress may slow and/or reduce absorption of drugs. OBJECTIVES: The present experiment investigated the hypothesis that stress slows absorption of drugs. METHODS: Twenty-four volunteers participated in a within-subjects design with three conditions, each lasting 70 min. Subjects watched a movie hypothesized to induce stress, subjects listened to music hypothesized to reduce stress, and in a control condition no stimuli were presented. Each condition was spaced 2 days or more apart. In each condition, subjects received 500 mg oral acetaminophen. Measures of stress and acetaminophen levels were obtained every 10 min. RESULTS: Indices of subjective stress and arousal and cortisol, were increased during the movie compared to control. Subjective arousal and cortisol were decreased during music compared to control. However, acetaminophen levels were the same across time in all three experimental conditions. CONCLUSIONS: There was no effect of the experimental manipulations on acetaminophen absorption, indicating that stress was not related to drug absorption. However, stress could play a role in other processes related to drug pharmacokinetics.
Authors:
Magne Arve Flaten; Ole Asli; Terje Simonsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-16
Journal Detail:
Title:  Psychopharmacology     Volume:  185     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-31     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  471-8     Citation Subset:  IM    
Affiliation:
Department of Psychology, SV-Fak., University of Tromsø, 9037 Tromsø, Norway. magnef@psyk.uit.no
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood,  pharmacokinetics*
Adult
Analgesics, Non-Narcotic / blood,  pharmacokinetics*
Arousal / physiology
Catecholamines / blood
Electroencephalography
Electromyography
Electrophysiology
Galvanic Skin Response / physiology
Gastrointestinal Motility / physiology
Humans
Hydrocortisone / blood
Intestinal Absorption
Isometric Contraction / physiology
Male
Myoelectric Complex, Migrating / physiology
Stomach / physiology
Stress, Psychological / metabolism*
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Catecholamines; 103-90-2/Acetaminophen; 50-23-7/Hydrocortisone

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