Document Detail


The effect of sterol regulatory element-binding protein 2 polymorphism on the serum lipid in northern Chinese subjects.
MedLine Citation:
PMID:  15547298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sterol regulatory element-binding protein 2 (SREBP-2) is an important nuclear transcription factor in the regulation of cellular cholesterol metabolism. To determine allele frequency of the 1784G>C polymorphism at the SREBP-2 locus and investigate the relationship between this polymorphism and serum lipid levels in Chinese people, we selected 486 individuals (118 men and 368 women) from the Xicheng District of Beijing. The subjects were divided into four groups: hypercholesterolemic subjects, hypertriglyceridemic subjects, combined hyperlipidemic subjects, and normal subjects. Serum lipid profiles were measured in all subjects, and 1784G>C was analyzed using polymerase chain reaction-restriction fragment length polymorphism analysis. There was no significant difference in genotype frequencies or allele frequencies of this polymorphism between the hyperlipidemic and control groups. The serum total cholesterol (TC) and LDL cholesterol (LDL-C) levels of the individuals carrying the C allele were higher than the noncarriers in both males and females in the hypercholesterolemic group, but statistical significance was only observed in females. The results of this study indicate that the SREBP-2 polymorphism is related to elevated concentrations of serum TC and LDL-C in hypercholesterolemic subjects. Further work is necessary to confirm the role of 1784G>C in the development of hyperlipidemia.
Authors:
Xueying Duan; Wenli Zhu; Yong Li; Zhentao Zhang; Yao Zhao; Jingjing Dao; Ying Xiao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-16
Journal Detail:
Title:  Journal of lipid research     Volume:  46     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-03     Completed Date:  2005-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  IM    
Affiliation:
Department of Nutrition and Food Hygiene, Peking University Health Science Center, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles
Body Mass Index
China
Cholesterol, LDL / blood
DNA / metabolism
DNA-Binding Proteins / genetics*
Female
Gene Frequency
Genotype
Humans
Hypercholesterolemia / blood
Lipid Metabolism
Lipids / blood*
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Sex Factors
Sterol Regulatory Element Binding Protein 2
Transcription Factors / genetics*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, LDL; 0/DNA-Binding Proteins; 0/Lipids; 0/SREBF2 protein, human; 0/Sterol Regulatory Element Binding Protein 2; 0/Transcription Factors; 0/Triglycerides; 9007-49-2/DNA

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