Document Detail

The effect of splenectomy in hereditary spherocytosis by dual angle laser light cytometry.
MedLine Citation:
PMID:  9054697     Owner:  NLM     Status:  MEDLINE    
We have applied dual angle laser scattering cytometry (DALC), which provides objective assessment of spherocytosis, to study the changes of hereditary spherocytosis (HS) red cell populations after splenectomy. Eighty unsplenectomized HS patients (32 mild, 37 moderate and 11 severe cases), 26 splenectomized HS patients (SHS, formerly 21 moderate and five severe cases) and 140 controls were studied. SHS were similar to unsplenectomized mild HS cases, with homogeneous red cell volume distribution and spherocytosis. Spherocytosis in SHS was significantly higher when compared with controls (P < 0.001) but less when compared with unsplenectomized HS patients (P < 0.01).
M P Ricard; F Gilsanz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  18     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-08-08     Completed Date:  1997-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-51     Citation Subset:  IM    
Hematología, Hospital Central de Cruz Roja, Madrid, Spain.
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MeSH Terms
Erythrocyte Indices
Flow Cytometry / methods*
Hemoglobinometry / methods*
Hemoglobins / analysis
Spherocytosis, Hereditary / physiopathology,  surgery*
Reg. No./Substance:

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