| An effect-specific track-length model for radiations of intermediate to high LET. | |
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MedLine Citation:
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PMID: 2023987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A model for the induction of transformation, mutation, and cell killing by radiations of intermediate to high linear energy transfer (LET) is presented. The mathematical formulation presupposes a constant probability per unit path length for damaging multiple subcellular targets by radiation of a fixed LET. The coupling between effects is accounted for through an explicit calculation of the probability that any specific combination of effects occurs in a given cell. This feature avoids the false assumption that cell killing and mutation (or transformation) are independent events. The resulting model then is applied to data on the in vitro survival, mutation, and transformation of cells by radiations of varying LET. A summary of estimated parameter values is provided and calculations of the effect of cellular flattening on transformation are presented. |
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Authors:
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D J Crawford-Brown; W Hofmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiation research Volume: 126 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-06-06 Completed Date: 1991-06-06 Revised Date: 2001-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 162-70 Citation Subset: IM; S |
Affiliation:
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Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599-7400. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Survival
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radiation effects* Cell Transformation, Neoplastic / radiation effects* Dose-Response Relationship, Radiation Energy Transfer Mathematics Models, Theoretical* Mutation / radiation effects* Relative Biological Effectiveness |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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