Document Detail

The effect of sorbitol and activated charcoal on serum theophylline concentrations after slow-release theophylline.
MedLine Citation:
PMID:  3802699     Owner:  NLM     Status:  MEDLINE    
The effect of the addition of sorbitol to an oral regimen of multiple doses of activated charcoal on serum theophylline concentrations was studied after the ingestion of slow-release theophylline in nine healthy male volunteers. At 6, 7, 8, 10, and 12 hours after Theo-24 (1200 mg/70 kg) ingestion, each subject received, in a randomized crossover design, either 300 ml water, 20 gm activated charcoal in water, or 20 gm activated charcoal in water plus 75 ml 70% sorbitol at 6 and 8 hours only. The serum AUCs from 6 to 30 hours after Theo-24 ingestion during the water, charcoal, and charcoal plus sorbitol phases were 305 +/- 16, 113 +/- 6, and 85 +/- 10 mg-hr/L (mean +/- SE), respectively. We conclude that the addition of sorbitol to an oral regimen of multiple doses of activated charcoal decreased the serum theophylline concentrations after therapeutic doses of slow-release theophylline to a significantly greater extent than did the activated charcoal regimen alone.
M J Goldberg; R Spector; G D Park; G F Johnson; P Roberts
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  41     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-03-02     Completed Date:  1987-03-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  108-11     Citation Subset:  AIM; IM    
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MeSH Terms
Charcoal / pharmacology*
Delayed-Action Preparations
Drug Interactions
Sorbitol / pharmacology*
Statistics as Topic
Theophylline / administration & dosage,  metabolism*
Grant Support
Reg. No./Substance:
0/Delayed-Action Preparations; 16291-96-6/Charcoal; 50-70-4/Sorbitol; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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