Document Detail


The effect of sorbitol and activated charcoal on serum theophylline concentrations after slow-release theophylline.
MedLine Citation:
PMID:  3802699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the addition of sorbitol to an oral regimen of multiple doses of activated charcoal on serum theophylline concentrations was studied after the ingestion of slow-release theophylline in nine healthy male volunteers. At 6, 7, 8, 10, and 12 hours after Theo-24 (1200 mg/70 kg) ingestion, each subject received, in a randomized crossover design, either 300 ml water, 20 gm activated charcoal in water, or 20 gm activated charcoal in water plus 75 ml 70% sorbitol at 6 and 8 hours only. The serum AUCs from 6 to 30 hours after Theo-24 ingestion during the water, charcoal, and charcoal plus sorbitol phases were 305 +/- 16, 113 +/- 6, and 85 +/- 10 mg-hr/L (mean +/- SE), respectively. We conclude that the addition of sorbitol to an oral regimen of multiple doses of activated charcoal decreased the serum theophylline concentrations after therapeutic doses of slow-release theophylline to a significantly greater extent than did the activated charcoal regimen alone.
Authors:
M J Goldberg; R Spector; G D Park; G F Johnson; P Roberts
Related Documents :
11090559 - Effects of hypoxia and hypercapnia on circadian rhythms in the golden hamster (mesocric...
3131629 - Impaired glucose metabolism in surgical patients improved by intravenous nutrition: ass...
669869 - Exercise, induced bronchospasm in asthmatic children as a dose-response model for theop...
3663879 - Pharmacokinetic analysis of sustained-release dosage forms of theophylline in humans: c...
12568539 - Simple and rapid determination of thiabendazole, imazalil, and o-phenylphenol in citrus...
6861439 - Theophylline kinetics in a geriatric group.
23425779 - Clinical implications of antiretroviral drug interactions with warfarin: a case-control...
11708699 - The metabolism of orally ingested 19-nor-4-androstene-3,17-dione and 19-nor-4-androsten...
3264549 - Epidermal growth factor-induced growth retardation in the newborn rat: quantitation and...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  41     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-03-02     Completed Date:  1987-03-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  108-11     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Charcoal / pharmacology*
Delayed-Action Preparations
Drug Interactions
Humans
Kinetics
Male
Sorbitol / pharmacology*
Statistics as Topic
Theophylline / administration & dosage,  metabolism*
Grant Support
ID/Acronym/Agency:
RR0059/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 16291-96-6/Charcoal; 50-70-4/Sorbitol; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physiologic and subjective changes from smokeless tobacco withdrawal.
Next Document:  Effect of food on the absorption of enteric-coated aspirin: correlation with gastric residence time.