Document Detail

The effect of some urinary stone inhibitors on membrane interaction potentials of stone crystals.
MedLine Citation:
PMID:  2442419     Owner:  NLM     Status:  MEDLINE    
The effect of stone growth inhibitors (citrate, pyrophosphate, ethane diphosphonate, methane diphosphonate, chondroitin sulfate A, chondroitin sulfate C, heparin and ribonucleic acid) on crystal-membrane interactions of whewellite, weddellite, apatite, brushite, struvite, uric acid, monosodium urate and quartz (control) stones was quantitated. As a model for the initial retention of microcrystals by kidney epithelial membranes, crystal-induced membranolysis of red blood cells served as a measure of crystal-membrane interactions. The inhibitors induced changes in hemolytic potential from approximately 320 per cent enhancement to 80 per cent inhibition. No inhibitor behaved the same way for all crystals studied. However, some crystals showed consistent trends in altered hemolytic potential in the presence of inhibitors. These crystals included weddellite and sodium urate, which were inhibited consistently, and apatite and quartz, which were enhanced consistently. Whewellite, uric acid, brushite and struvite exhibited mixed patterns in the altered hemolytic potentials owing to the inhibitors.
N S Mandel; G S Mandel; A T Hasegawa
Related Documents :
17664859 - Status of uric acid management in hypertensive subjects.
6895439 - Hyperuricemia and gout: an update.
6748949 - Hypouricemia in cirrhosis reflects hemodynamic alterations.
10461109 - Excretion of tamm-horsfall protein in patients with uric acid stones.
9262469 - Sulfur and hydrogen isotope anomalies in meteorite sulfonic acids.
6985799 - Fibrin membrane endowed with biological function. v. multienzyme complex of uricase, ca...
10757719 - Prenylated benzoic acid derivatives from ferula kuhistanica.
23263959 - Single amino acid substitutions in hxt2.4 from scheffersomyces stipitis lead to improve...
3459479 - Acid solutions enhance bone-inducing activity of a murine osteosarcoma.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  138     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-05     Completed Date:  1987-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  557-62     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calcium Oxalate / antagonists & inhibitors*
Chondroitin Sulfates / pharmacology
Citrates / pharmacology
Citric Acid
Diphosphates / pharmacology
Diphosphonates / pharmacology
Erythrocyte Membrane / drug effects*
Etidronic Acid / pharmacology
Heparin / pharmacology
RNA / pharmacology
Urinary Calculi / analysis*
Grant Support
Reg. No./Substance:
0/Citrates; 0/Diphosphates; 0/Diphosphonates; 1984-15-2/methylene diphosphonate; 25454-23-3/Calcium Oxalate; 2809-21-4/Etidronic Acid; 63231-63-0/RNA; 77-92-9/Citric Acid; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Vasoactive intracavernous pharmacotherapy for the treatment of erectile impotence in men with spinal...
Next Document:  Cavitary lung nodules associated with combination chemotherapy containing bleomycin.