Document Detail


The effect of some urinary stone inhibitors on membrane interaction potentials of stone crystals.
MedLine Citation:
PMID:  2442419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of stone growth inhibitors (citrate, pyrophosphate, ethane diphosphonate, methane diphosphonate, chondroitin sulfate A, chondroitin sulfate C, heparin and ribonucleic acid) on crystal-membrane interactions of whewellite, weddellite, apatite, brushite, struvite, uric acid, monosodium urate and quartz (control) stones was quantitated. As a model for the initial retention of microcrystals by kidney epithelial membranes, crystal-induced membranolysis of red blood cells served as a measure of crystal-membrane interactions. The inhibitors induced changes in hemolytic potential from approximately 320 per cent enhancement to 80 per cent inhibition. No inhibitor behaved the same way for all crystals studied. However, some crystals showed consistent trends in altered hemolytic potential in the presence of inhibitors. These crystals included weddellite and sodium urate, which were inhibited consistently, and apatite and quartz, which were enhanced consistently. Whewellite, uric acid, brushite and struvite exhibited mixed patterns in the altered hemolytic potentials owing to the inhibitors.
Authors:
N S Mandel; G S Mandel; A T Hasegawa
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  138     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-05     Completed Date:  1987-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  557-62     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Calcium Oxalate / antagonists & inhibitors*
Chondroitin Sulfates / pharmacology
Citrates / pharmacology
Citric Acid
Crystallization
Diphosphates / pharmacology
Diphosphonates / pharmacology
Erythrocyte Membrane / drug effects*
Etidronic Acid / pharmacology
Hemolysis
Heparin / pharmacology
Humans
RNA / pharmacology
Urinary Calculi / analysis*
Grant Support
ID/Acronym/Agency:
AM 30579/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Citrates; 0/Diphosphates; 0/Diphosphonates; 1984-15-2/methylene diphosphonate; 25454-23-3/Calcium Oxalate; 2809-21-4/Etidronic Acid; 63231-63-0/RNA; 77-92-9/Citric Acid; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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