| The effect of somatostatin, gabexate mesilate and dextran 40 on the microcirculation in sodium taurocholate-induced pancreatitis. | |
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MedLine Citation:
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PMID: 1285368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo microscopy was performed to assess the effect of dextran 40, gabexate mesilate and somatostatin on the microcirculation in sodium taurocholate-induced pancreatitis in rats. Intraductal infusion of 0.4 ml of a 4% solution of sodium taurocholate decreased capillary blood flow, induced capillary stasis and increased vascular permeability in the head of the pancreas. Dextran 40, gabexate mesilate and somatostatin improved capillary blood flow in the initial phase of acute pancreatitis significantly and prevented stasis in 5 of 9, 3 of 8 and 7 of 10 (p < 0.05) cases. Only dextran 40 reduced the increase of vascular permeability. Decrease of capillary blood flow, capillary stasis and vascular permeability changes are important factors contributing to the pathogenesis of sodium taurocholate-induced pancreatitis. Dextran 40, gabexate mesilate and somatostatin exert a beneficial effect on the microcirculatory changes in this model of acute pancreatitis. |
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Authors:
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K Kusterer; M Enghofer; T Poschmann; K H Usadel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Hungarica Volume: 80 ISSN: 0231-424X ISO Abbreviation: Acta Physiol Hung Publication Date: 1992 |
Date Detail:
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Created Date: 1994-07-05 Completed Date: 1994-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309201 Medline TA: Acta Physiol Hung Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 407-15 Citation Subset: IM |
Affiliation:
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Dept. of Endocrinology, Johann Wolfgang Goethe-University, Frankfurt, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillary Permeability / drug effects Dextrans / pharmacology* Female Fluorescein-5-isothiocyanate Gabexate / pharmacology* Microcirculation / drug effects Pancreas / blood supply Pancreatitis / chemically induced, physiopathology* Rats Rats, Wistar Regional Blood Flow / drug effects Somatostatin / pharmacology* Taurocholic Acid* |
| Chemical | |
Reg. No./Substance:
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3326-32-7/Fluorescein-5-isothiocyanate; 39492-01-8/Gabexate; 51110-01-1/Somatostatin; 81-24-3/Taurocholic Acid; 9004-54-0/Dextrans |
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