Document Detail

The effect of somatostatin on experimental intestinal obstruction.
MedLine Citation:
PMID:  2893593     Owner:  NLM     Status:  MEDLINE    
The effect of somatostatin (SS-14) was tested in an anesthetized rabbit model of closed-loop ileal obstruction. Experimental groups included (1) immediate treatment (N = 6) receiving SS-14 2,000 pmol X kg-1 X h-1 intravenously (I.V.) beginning at the time of ileal obstruction, (2) delayed treatment (N = 5) receiving SS-14 beginning 6 hours following ileal obstruction, and (3) control (N = 6) receiving only hydration. After 24 hours, all rabbits were killed. Significantly decreased intestinal luminal volume and sodium and potassium output was observed with both immediate and delayed SS-14 treatment when compared to control. Additionally, the gross and microscopic pathologic features of intestinal distension, inflammation, and necrosis seen in control rabbits were absent in rabbits treated with SS-14. The known broad spectrum of physiologic activity of SS-14 on the gastrointestinal tract appeared beneficial in this rabbit model of intestinal obstruction.
S J Mulvihill; T N Pappas; E W Fonkalsrud; H T Debas
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  207     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-07     Completed Date:  1988-03-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  AIM; IM    
Department of Surgery, University of California, San Francisco 94143-0104.
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MeSH Terms
Ileal Diseases / drug therapy*
Ileum / metabolism,  pathology
Intestinal Obstruction / drug therapy*
Potassium / metabolism
Sodium / metabolism
Somatostatin / therapeutic use*
Time Factors
Grant Support
Reg. No./Substance:
51110-01-1/Somatostatin; 7440-09-7/Potassium; 7440-23-5/Sodium

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