Document Detail


The effect of somatostatin analogue (SMS 201-995) on pancreatic blood flow.
MedLine Citation:
PMID:  3194830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of somatostatin analogue SMS 201-995 on pancreatic blood flow was studied. In 24 dogs all vessels to the pancreas, except for the pancreaticoduodenal artery and vein, were divided. A flow probe was placed around the pancreaticoduodenal artery. The animals were divided into four groups. Control animals received a subcutaneous injection of 0.5 ml of normal saline solution. Treated animals received 0.002, 0.02, and 0.2 mg/kg of SMS 201-995 at the outset of the experiment. Mean systemic arterial blood pressure, cardiac output, and serum amylase values were monitored, in addition to pancreaticoduodenal blood flow. SMS 201-995 produced a prompt and sustained decrease in pancreatic blood flow in all treated groups compared with control animals without alteration of systemic hemodynamics. This suggests that SMS 201-995 decreases local vascular resistance, which results in decreased pancreatic blood flow.
Authors:
D R Conway; G Djuricin; R A Prinz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  104     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-10     Completed Date:  1989-01-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1024-30     Citation Subset:  AIM; IM    
Affiliation:
Research Service, Hines Veterans Administration Hospital, Ill.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries
Blood Pressure
Cardiac Output
Dogs
Duodenum / blood supply
Octreotide / pharmacology*
Pancreas / blood supply,  drug effects*,  physiology
Regional Blood Flow / drug effects*
Chemical
Reg. No./Substance:
83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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