| The effect of somatostatin analogue (SMS 201-995) on pancreatic blood flow. | |
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MedLine Citation:
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PMID: 3194830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of somatostatin analogue SMS 201-995 on pancreatic blood flow was studied. In 24 dogs all vessels to the pancreas, except for the pancreaticoduodenal artery and vein, were divided. A flow probe was placed around the pancreaticoduodenal artery. The animals were divided into four groups. Control animals received a subcutaneous injection of 0.5 ml of normal saline solution. Treated animals received 0.002, 0.02, and 0.2 mg/kg of SMS 201-995 at the outset of the experiment. Mean systemic arterial blood pressure, cardiac output, and serum amylase values were monitored, in addition to pancreaticoduodenal blood flow. SMS 201-995 produced a prompt and sustained decrease in pancreatic blood flow in all treated groups compared with control animals without alteration of systemic hemodynamics. This suggests that SMS 201-995 decreases local vascular resistance, which results in decreased pancreatic blood flow. |
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Authors:
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D R Conway; G Djuricin; R A Prinz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 104 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-10 Completed Date: 1989-01-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1024-30 Citation Subset: AIM; IM |
Affiliation:
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Research Service, Hines Veterans Administration Hospital, Ill. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries Blood Pressure Cardiac Output Dogs Duodenum / blood supply Octreotide / pharmacology* Pancreas / blood supply, drug effects*, physiology Regional Blood Flow / drug effects* |
| Chemical | |
Reg. No./Substance:
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83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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