Document Detail

The effect of smoking on the outcome of in-vitro fertilization--embryo transfer.
MedLine Citation:
PMID:  2056020     Owner:  NLM     Status:  MEDLINE    
This study investigated the influence of cigarette smoking on the outcome of in-vitro fertilization-embryo transfer. Forty-one women under the age of 37 years, suffering from mechanical infertility, were suppressed with gonadotrophin releasing analogue from day 21 of the cycle. Twenty women were smokers and 21 women were non-smokers. Gonadotrophin releasing analogue was injected daily before ovarian stimulation with gonadotrophin was begun. The follicular phase was longer and the number of human menopausal gonadotrophin ampoules required to reach adequate stimulation were higher in smokers. The peak serum oestradiol level was not significantly different in smokers compared to non-smokers. However, follicular fluid levels of oestradiol were significantly lower in smokers than in non-smokers (657 +/- 367 versus 1077 +/- 786 ng/ml) respectively. Furthermore, the fertilization rate was also lower in smokers than in non-smokers (40.9 versus 61.7%) respectively. Four pregnancies were achieved in the non-smokers group, while only one ectopic pregnancy was diagnosed in the smokers group. These findings suggest that cigarette smoking has a detrimental effect on the outcome of in-vitro fertilization and embryo transfer.
A Elenbogen; S Lipitz; S Mashiach; J Dor; D Levran; Z Ben-Rafael
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  6     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-31     Completed Date:  1991-07-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  242-4     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Chaim Sheba Medical Centre, Tel Aviv University, Tel Hashomer, Israel.
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MeSH Terms
Cleavage Stage, Ovum / physiology
Embryo Transfer*
Fertilization in Vitro*
Hormones / blood
Oocytes / cytology
Smoking / blood,  physiopathology*
Reg. No./Substance:

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