Document Detail

The effect of smoking and drinking in oral and pharyngeal cancers: a case-control study in Uruguay.
MedLine Citation:
PMID:  16624486     Owner:  NLM     Status:  MEDLINE    
In the time period 1988-2000, a case-control study on oral and pharyngeal cancers was conducted among men in Montevideo, Uruguay. The study included 776 cases and 1501 controls. The cases were distributed by site in oral cancers (335 patients) and pharyngeal cancers (441 patients). Odds ratios for smoking were higher among participants with pharyngeal cancers compared with those with oral carcinomas, but there was no significant heterogeneity. On the contrary, alcohol drinking displayed statistically higher risks among those with pharyngeal carcinomas compared with patients with oral cancer (P-value for heterogeneity=0.01). The effect of alcohol was particularly strong for cancers of the hypopharynx. Our results raise the possibility that oral and pharyngeal carcinomas are in fact different entities. Further studies are needed in order to clarify this important point.
Eduardo De Stefani; Paolo Boffetta; Hugo Deneo-Pellegrini; Alvaro L Ronco; Giselle Acosta; Gilles Ferro; Fernando Oreggia; Juan Leiva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-18
Journal Detail:
Title:  Cancer letters     Volume:  246     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2006-12-26     Completed Date:  2007-04-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  282-9     Citation Subset:  IM    
Grupo de Epidemiología, Departamento de Anatomía Patológica, Facultad de Medicina, Hospital de Clínicas, Avenida Brasil 3080 dep 402, 11300 Montevideo, Uruguay.
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MeSH Terms
Age Distribution
Aged, 80 and over
Alcohol Drinking / adverse effects*
Case-Control Studies
Interviews as Topic
Middle Aged
Mouth Neoplasms / etiology*
Odds Ratio
Pharyngeal Neoplasms / etiology*
Smoking / adverse effects*
Social Class

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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