| The effect of small changes in hematocrit on nitric oxide transport in arterioles. | |
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MedLine Citation:
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PMID: 20560785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the development of a mathematical model that quantifies the effects of small changes in systemic hematocrit (Hct) on the transport of nitric oxide (NO) in the microcirculation. The model consists of coupled transport equations for NO and oxygen (O2) and accounts for both shear-induced NO production by the endothelium and the effect of changing systemic Hct on the rate of NO production and the rate of NO scavenging by red blood cells. To incorporate the dependence of the plasma layer width on changes in Hct, the model couples the hemodynamics of blood in arterioles with NO and O2 transport in the plasma layer. A sensitivity analysis was conducted to determine the effects of uncertain model parameters (the thicknesses of endothelial surface layers and diffusion coefficients of NO and O2 in muscle tissues and vascular walls) on the model's predictions. Our analysis reveals that small increases in Hct may raise NO availability in the vascular wall. This finding sheds new light on the experimental data that show that the blood circulation responds to systematic increases of Hct in a manner that is consistent with increasing NO production followed by a plateau. |
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Authors:
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Krishna Sriram; Beatriz Y Salazar Vázquez; Ozlem Yalcin; Paul C Johnson; Marcos Intaglietta; Daniel M Tartakovsky |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-09 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 14 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: 2011-07-18 Revised Date: 2012-01-16 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 175-85 Citation Subset: IM |
Affiliation:
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Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, California 92093-0412, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / metabolism* Endothelium, Vascular / metabolism Hematocrit* Humans Microcirculation Models, Biological Nitric Oxide / biosynthesis, metabolism* Oxygen / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01-HL 062354/HL/NHLBI NIH HHS; R01-HL 076182/HL/NHLBI NIH HHS; R24-HL 064395/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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