Document Detail

The effect of skeletal muscle ventricle pouch pressure on muscle blood flow.
MedLine Citation:
PMID:  1532516     Owner:  NLM     Status:  MEDLINE    
Skeletal muscle powered assist ventricles (SMV) are being investigated in animal studies as a treatment for heart failure. Muscle fatigue is almost always dependent upon muscle capillary blood flow. This study examined the relationship between SMV intrapouch pressure and blood flow to the circumferential muscle in a working SMV with a mock circulation. The unconditioned rectus abdominis muscle was used to create an in situ SMV in five dogs. Muscle blood flow was measured by both the radioactive microsphere and the electromagnetic flow probe method as the pouch pressure was varied between 10 and 70 mmHg and as the SMV was stimulated to contract at a rate of 20 min-1. The correlation coefficient for the two methods was 0.908. At pouch pressures of 10, 40, and 70 mmHg, the respective blood flow values were 22.60 +/- 2.50 (1 SEM), 12.20 +/- 2.10, and 4.40 +/- 0.74 ml min-1 (p less than 0.05). When they were corrected for muscle weight, the mean blood flow values at these same pouch pressures were 0.28 +/- 0.03, 0.15 +/- 0.03, and 0.05 +/- 0.01 ml min-1 g-1, respectively (p less than 0.05). SMV output was measured for each pouch pressure that was tested. Pouch output, expressed as ml min-1, was 458 +/- 20 (1 SEM) at an SMV diastolic pouch pressure of 10 mmHg, 309 +/- 22 at a pouch pressure of 40 mmHg, and 103 +/- 6 at a pouch pressure of 70 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS)
S F Badylak; J E Wessale; L A Geddes; W A Tacker; W Janas
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  38     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1992 Jan-Mar
Date Detail:
Created Date:  1992-05-07     Completed Date:  1992-05-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  66-71     Citation Subset:  IM    
Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907.
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MeSH Terms
Abdominal Muscles / blood supply*
Blood Flow Velocity
Counterpulsation / methods*
Electric Stimulation Therapy
Heart-Assist Devices*
Microcirculation / physiology
Muscle Contraction / physiology
Muscles / transplantation*
Surgical Flaps
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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