Document Detail

The effect of a single bout of exhaustive exercise on muscle carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus.
MedLine Citation:
PMID:  10928236     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to estimate whether a single bout of exhaustive exercise influences the glycogen and triglyceride (TG) content in red and white gastrocnemius muscle and in the liver of rats with experimental type 2 diabetes. Experiments were carried out on male Wistar rats fed from 8 to 11 weeks of age with isocaloric standard or high-fat diet (HFD) with a previous injection of low-dose of streptozotocin (STZ) or vehicle at 2 days of age (I, control group; II, HFD; III, STZ; IV, STZ + HFD). Group IV (STZ + HFD) represents a model of type 2 diabetes. Basal liver glycogen was markedly lower in all the studied groups compared to controls. Glycogen concentration after exercise fell significantly in the examined tissues in all groups in comparison to basal conditions. A significant TG accumulation in examined tissues was observed in all the studied groups in comparison to controls. Exercise decreased tissue TG content in all the groups, but it remained significantly higher in the experimental groups vs. control. We conclude that in this model of type 2 diabetes, a single bout of exercise reveals defective utilization of tissue carbohydrates and lipids.
M Straczkowski; I Kowalska; J Górski; I Kinalska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta diabetologica     Volume:  37     ISSN:  0940-5429     ISO Abbreviation:  Acta Diabetol     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-11-28     Completed Date:  2000-11-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9200299     Medline TA:  Acta Diabetol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  IM    
Department of Endocrinology, Medical School, Białystok, Poland.
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MeSH Terms
Blood Glucose / metabolism
Diabetes Mellitus, Experimental / metabolism,  physiopathology*
Diabetes Mellitus, Type 2 / metabolism*
Disease Models, Animal
Glycogen / metabolism*
Insulin / blood
Liver / metabolism
Muscle Fibers, Fast-Twitch / metabolism
Muscle, Skeletal / metabolism*
Physical Exertion / physiology*
Rats, Wistar
Triglycerides / metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 11061-68-0/Insulin; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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