| The effect of simvastatin on the survival of ischaemic skin flap: an experimental study in rats. | |
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MedLine Citation:
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PMID: 19926543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombomodulin (TM) is down-regulated from the vascular endothelial surfaces and corresponds to disturbed dermal blood flow and microthrombus formation in the ischaemic skin flap. We examined the therapeutic potential of simvastatin which up-regulates endothelial cell TM expression and activity in the dorsal ischaemic skin flap model. The study was carried out on 30 rats, divided into three groups. Group 1 was treated with simvastatin at a dose of 5mgkg(-1) day(-1) by intraperitoneal injection. Group 2 was treated with 1mgkg(-1) day(-1) with a phosphate-buffered saline for 7 days. Group 3 was the control group. Tissue blood flow, vascularisation and the survival rate of the skin flaps from each group were compared. The mean surviving area of group 1 was higher than groups 2 and 3 (p<0.05). The blood flow change rate did not decrease in the treatment group in contrast to the control groups at 3cm and 5cm (p<0.05). Microangiography demonstrated decreased flap vascularity in groups 2 and 3. There was no evidence of necrosis or positive peroxidase staining for TM in group 1 at 3cm and 5cm., although it was negative in groups 2 and 3. In this study, it was demonstrated that simvastatin prevented shedding of endothelial TM and contributed to flap survival. |
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Authors:
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Fatih Uygur; Nurettin Noyan; Aptullah Hahaolu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of plastic, reconstructive & aesthetic surgery : JPRAS Volume: 63 ISSN: 1878-0539 ISO Abbreviation: J Plast Reconstr Aesthet Surg Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264239 Medline TA: J Plast Reconstr Aesthet Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1723-32 Citation Subset: IM |
Copyright Information:
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Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, Selimiye Mahallesi Tıbbiye Caddesi 34 668, Üsküdar, Istanbul, Turkey. fatihuygur@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography
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methods Animals Graft Survival / drug effects* Injections, Intraperitoneal Laser-Doppler Flowmetry Male Random Allocation Rats Rats, Sprague-Dawley Simvastatin / administration & dosage, pharmacology* Statistics, Nonparametric Surgical Flaps / blood supply* Thrombomodulin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Thrombomodulin; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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