| The effect of simulated obstructive apnea and hypopnea on aortic diameter and blood pressure. | |
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MedLine Citation:
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PMID: 21393398 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract BACKGROUND: Preliminary evidence supports an association between obstructive sleep apnea (OSA) and thoracic aortic dilatation. The mechanisms through which OSA may promote thoracic aortic dilatation are incompletely understood. Therefore, we studied the acute effects of simulated apnea and hypopnea on aortic diameter and blood pressure in humans. METHODS: In 20 healthy volunteers the diameter of the aortic root was measured by echocardiography and peripheral blood pressure was continuously recorded prior, during and immediately after simulated obstructive hypopnea (inspiration through threshold load), simulated obstructive apnea (Mueller maneuver), end-expiratory central apnea and normal breathing in randomized order. RESULTS: Proximal aortic diameter increased significantly during inspiration through a threshold load (+6.48% (SE3.03), p=0.007), but not during Mueller maneuver (+3.86% (SE2.71), p=0.336) or end-expiratory central apnea (+0.62% (SE 2.94), p=0.445). Maneuver-induced changes in mean blood pressure were observed during inspiration through a threshold load (-10.5 (SE2.2) mmHg, p<0.001), the Mueller maneuver (-8.8 (SE2.4) mmHg, p<0.001), and end-expiratory central apnea (-4.2 (SE1.4) mmHg, p=0.052). There was a significant increase in mean blood pressure on release of threshold load inspiration (+8.1 (SE2.9) mmHg, p=0.002), Mueller maneuver (+10.7 (SE2.9) mmHg, p<0.001) and end-expiratory central apnea (+10.6 (SE2.5) mmHg, p<0.001). CONCLUSION: Simulated obstructive hypopnea/apnea and central apnea induced considerable changes in blood pressure and obstructive hypopnea was associated with an increase in proximal aortic diameter. Further studies are needed to investigate effects of apnea and hypopnea on transmural aortic pressure and aortic diameter in order to define the role of OSA in the pathogenesis of aortic dilatation. |
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Authors:
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Anne-Christin Stöwhas; Mehdi Namdar; Patric Biaggi; Erich W Russi; Konrad E Bloch; John R Stradling; Malcolm Kohler |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-10 |
Journal Detail:
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Title: Chest Volume: - ISSN: 1931-3543 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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