| The effect of sildenafil on oesophageal motor function in healthy subjects and patients with nutcracker oesophagus. | |
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MedLine Citation:
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PMID: 14651597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 5 phosphodiesterase terminates the action of nitric oxide (NO) induced 3',5'-cyclic monophosphate (cGMP). Sildenafil inhibits this phosphodiesterase, increases cellular cGMP concentrations and enhances NO-induced smooth muscle relaxation. We investigated the effect of sildenafil on the oesophageal motor function of healthy subjects and patients with nutcracker oesophagus. Eight healthy volunteers and nine patients with nutcracker oesophagus participated in this study. The participants underwent oesophageal manometries on two separate days after either 20 mL of distilled water or 0.8 mg kg-1 sildenafil dissolved in 20 mL of water was infused into the stomach. Lower oesophageal sphincter (LOS) resting pressure, the duration of LOS relaxation and the amplitudes of oesophageal pressure waves were examined before, and 7.5, 15, 30 and 60 min after either placebo or sildenafil. In both healthy subjects and patients with nutcracker oesophagus, sildenafil decreased resting LOS pressure and the amplitude of peristaltic pressure waves at 3, 8 and 13 cm above LOS. Sildenafil also prolonged the duration of LOS relaxation. It had no effect on the velocity of peristalsis or the amplitude of peristaltic pressure waves 18 cm above LOS. Sildenafil may be considered as an alternative treatment in nutcracker oesophagus although there are several limitations to be overcome. |
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Authors:
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J I Lee; H Park; J H Kim; S I Lee; J L Conklin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 15 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-01-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 617-23 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. hjpark21@yumc.yonsei.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Double-Blind Method Esophageal Motility Disorders / drug therapy*, physiopathology Esophagus / drug effects*, physiology Female Humans Male Manometry / methods Middle Aged Peristalsis / drug effects, physiology Piperazines / pharmacology*, therapeutic use Purines Statistics, Nonparametric Sulfones |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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