Document Detail

The effect of short-term indomethacin therapy on amniotic fluid volume.
MedLine Citation:
PMID:  15902132     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the effect of short-term (48 hour) indomethacin therapy on amniotic fluid volume. STUDY DESIGN: Patients who were admitted to Northwestern Memorial Hospital in preterm labor and who received indomethacin tocolysis were eligible for the study. Thirty-five patients with singleton gestations and 26 patients with twin gestations were enrolled. Amniotic fluid volumes were measured at baseline, at 48 hours after the initiation of indomethacin, and then every 24 hours thereafter for a maximum of 7 days. RESULTS: There were no significant changes in mean amniotic fluid volume subsequent to the administration of indomethacin at any of the time points that were measured. Among the 61 patients who received indomethacin, there were 2 cases of oligohydramnios (3.3%; 95% CI, 0.03%, 11.3%). In both cases, the amniotic fluid index returned to normal within 24 hours after the discontinuation of indomethacin. CONCLUSION: Short-term indomethacin therapy, in either singleton or twin gestations, does not cause a clinically significant change in amniotic fluid volume.
Julie C Sandruck; William A Grobman; Susan E Gerber
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  192     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-19     Completed Date:  2005-06-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1443-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Ill, USA.
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MeSH Terms
Amniotic Fluid / drug effects*,  metabolism*
Drug Administration Schedule
Indomethacin / administration & dosage*,  adverse effects*,  therapeutic use
Obstetric Labor, Premature / drug therapy*
Oligohydramnios / chemically induced,  epidemiology,  metabolism
Pregnancy, Multiple
Time Factors
Tocolytic Agents / administration & dosage*,  adverse effects*,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Tocolytic Agents; 53-86-1/Indomethacin

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