Document Detail


Effect of sex and ovarian hormones on carotid baroreflex resetting and function during dynamic exercise in humans.
MedLine Citation:
PMID:  22267388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To date, no studies have examined whether there are either sex- or ovarian hormone-related alterations in arterial baroreflex resetting and function during dynamic exercise. Thus we studied 16 young men and 18 young women at rest and during leg cycling at 50% heart rate (HR) reserve. In addition, 10 women were studied at three different phases of the menstrual cycle. Five-second pulses of neck pressure (NP) and neck suction (NS) from +40 to -80 Torr were applied to determine full carotid baroreflex (CBR) stimulus response curves. An upward and rightward resetting of the CBR function curve was observed during exercise in all groups with a similar magnitude of CBR resetting for mean arterial pressure (MAP) and HR between sexes (P > 0.05) and at different phases of the menstrual cycle (P > 0.05). For CBR control of MAP, women exhibited augmented pressor responses to NP at rest and exercise during mid-luteal compared with early and late follicular phases. For CBR control of HR, there was a greater bradycardic response to NS in women across all menstrual cycle phases with the operating point (OP) located further away from centering point (CP) on the CBR-HR curve during rest (OP-CP; in mmHg: -13 ± 3 women vs. -3 ± 3 men; P < 0.05) and exercise (in mmHg: -31 ± 2 women vs. -15 ± 3 men; P < 0.05). Collectively, these findings suggest that sex and fluctuations in ovarian hormones do not influence exercise resetting of the baroreflex. However, women exhibited greater CBR control of HR during exercise, specifically against acute hypertension, an effect that was present throughout the menstrual cycle.
Authors:
Areum Kim; Shekhar H Deo; James P Fisher; Paul J Fadel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-19
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  112     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-09-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1361-71     Citation Subset:  IM    
Affiliation:
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.
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MeSH Terms
Descriptor/Qualifier:
Baroreflex / physiology*
Bicycling / physiology
Blood Pressure / physiology
Carotid Arteries / physiology*
Estradiol / physiology*
Exercise / physiology*
Female
Heart Rate / physiology
Humans
Hypertension / physiopathology
Male
Menstrual Cycle / physiology
Sex Characteristics*
Young Adult
Grant Support
ID/Acronym/Agency:
HL-093167/HL/NHLBI NIH HHS; R01 HL093167/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
50-28-2/Estradiol
Comments/Corrections

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