Document Detail

The effect of selective umbilical embolization on the common umbilical artery pulsatility index and umbilical vascular resistance in fetal sheep.
MedLine Citation:
PMID:  1753067     Owner:  NLM     Status:  MEDLINE    
In eight anaesthesized fetal sheep (gestational age 112-127 days; term 147 days), embolization of the umbilical placental circulation was performed in order to evaluate the response of the umbilical artery pulsatility index to an exclusive increase in umbilical vascular resistance. Measurements were performed using a 20 MHz pulsed Doppler transducer and an electromagnetic flow meter mounted on the common umbilical artery and catheters at the aortic trifurcation and in one of the umbilical veins. Umbilical vascular resistance was calculated according the Poiseuille equation as the ratio of aortic to umbilical venous pressure gradient and umbilical blood flow. Microspheres were administered at 15-min intervals through a catheter in one of the cotyledonary arteries, until fetal heart rate had decreased beneath 100 beats/min or had become arrhythmic. The period of examination per fetus varied between 60 and 120 min, after which cardiac decompensation occurred. During this period, umbilical perfusion pressure increased from 20.3 +/- 4.9 to 28.1 +/- 4.7 mmHg (SD; P less than 0.01), umbilical blood flow (ml/min) decreased from 342 +/- 127 to 115 +/- 99 mmHg (SD; P less than 0.01), umbilical vascular resistance increased from 0.065 +/- 0.022 to 0.342 +/- 0.150 mmHg.min/ml (P less than 0.01) and common umbilical artery pulsatility index increased from 0.97 +/- 0.23 to 4.03 +/- 1.69 (P less than 0.01). Fetal heart rate did not change significantly (168 +/- 33 prior to cardiac decompensation versus 178 +/- 19 beats/min at baseline condition). The linear correlation between common umbilical artery pulsatility index and umbilical vascular resistance varied between 0.83 and 0.99 and the average correlation was 0.93 (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
G J Muijsers; H van Huisseling; T H Hasaart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  15     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1992-01-27     Completed Date:  1992-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-67     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, State University Limburg, Maastricht, The Netherlands.
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MeSH Terms
Blood Flow Velocity
Blood Pressure
Embolism / physiopathology
Fetus / blood supply*
Heart Rate, Fetal
Pulsatile Flow
Umbilical Arteries / physiology*
Vascular Resistance

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