Document Detail

The effect of salbutamol on performance in elite nonasthmatic athletes.
MedLine Citation:
PMID:  1435165     Owner:  NLM     Status:  MEDLINE    
The effect of salbutamol on performance was studied in seven male nonasthmatic highly trained (VO2max > or = 60 x min-1) cyclists. Salbutamol (S = 2 puffs = 200 micrograms) or placebo (P) was administered by metered-dose inhaler, through a spacer device, 20 min prior to testing in a double-blind, randomized cross-over design. Testing sessions on a cycle ergometer included the measurement of maximal oxygen uptake (VO2max), peak power, maximal heart rate, and pulmonary function. A timed sprint to exhaustion was performed after 45 min of exercise at 70% of VO2max, and a Wingate anaerobic test was used to measure total work and peak power. There was a nonsignificant decrease in VO2max (P = 63.5 +/- 3.2; S = 62.6 +/- 3.3 x min-1). No difference was found in peak power, maximum heart rate, endurance sprint time, Wingate peak power, or total work. After an anticipated baseline increase was taken into account, the pattern of change in FEV1 over time did not differ between salbutamol and placebo. It was concluded that a therapeutic dose of aerosol salbutamol does not have an ergogenic effect in elite nonasthmatic athletes, and it is therefore recommended that inhaled salbutamol continue to be permitted in international competition for individuals with exercise induced bronchospasm.
W H Meeuwisse; D C McKenzie; S R Hopkins; J D Road
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  24     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-27     Completed Date:  1992-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1161-6     Citation Subset:  IM; S    
Division of Sport Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Albuterol / pharmacology*
Double-Blind Method
Forced Expiratory Volume / drug effects
Heart Rate / drug effects
Oxygen Consumption / drug effects
Respiratory Function Tests
Task Performance and Analysis*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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