Document Detail

The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats.
MedLine Citation:
PMID:  17962007     Owner:  NLM     Status:  MEDLINE    
In this study, the aphrodisiac activities of Crocus sativus stigma aqueous extract and its constituents, safranal and crocin, were evaluated in male rats. The aqueous extract (80, 160 and 320mg/kg body wt.), crocin (100, 200 and 400mg/kg body wt.), safranal (0.1, 0.2 and 0.4ml/kg), sildenafil (60mg/kg body wt., as a positive control) and saline were administered intraperitoneally to male rats. Mounting frequency (MF), intromission frequency (IF), erection frequency (EF), mount latency (ML), intromission latency (IL) and ejaculation latency (EL) were the factors evaluated during the sexual behavior study. Crocin, at all doses, and the extract, especially at doses 160 and 320mg/kg body wt., increased MF, IF and EF behaviors and reduced EL, IL and ML parameters. Safranal did not show aphrodisiac effects. The present study reveals an aphrodisiac activity of saffron aqueous extract and its constituent crocin.
H Hosseinzadeh; T Ziaee; A Sadeghi
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Publication Detail:
Type:  Journal Article     Date:  2007-10-24
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  15     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  491-5     Citation Subset:  IM    
Pharmacology and Toxicology Department, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 1365-91775, Mashhad, IR Iran.
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MeSH Terms
Aphrodisiacs / analysis
Carotenoids / analysis,  pharmacology*,  therapeutic use
Crocus / chemistry*
Cyclohexenes / analysis,  pharmacology*,  therapeutic use
Plant Extracts / pharmacology*,  therapeutic use
Rats, Wistar
Sexual Behavior, Animal / drug effects*
Sexual Dysfunction, Physiological / drug therapy
Sexual Dysfunctions, Psychological / drug therapy
Terpenes / analysis,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Aphrodisiacs; 0/Cyclohexenes; 0/Plant Extracts; 0/Terpenes; 116-26-7/safranal; 36-88-4/Carotenoids; 42553-65-1/crocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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