Document Detail


The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous administration of three model substrates.
MedLine Citation:
PMID:  2570603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of pretreatment for 7 days with either roxatidine acetate 75 mg twice daily or cimetidine 200 mg four times daily on the kinetics of antipyrine (AP), trimethadione (TMO) and indocyanine green (ICG) was studied in seven healthy, male, nonsmoking subjects. After pretreatment with cimetidine, the plasma clearances (CL) of AP and TMO were significantly lower and the elimination half-life (t1/2) of AP was significantly increased. The volumes of distribution (V) of AP and TMO were not affected. After roxatidine acetate, the pharmacokinetics of AP and TMO were unchanged. The cumulative renal excretion (% dose) and formation clearance of 3-hydroxymethyl-3-nor-antipyrine (NORA) were lowered by cimetidine treatment, but not following the administration of roxatidine acetate. ICG clearance was not changed significantly by either pretreatment. The results of this study show that roxatidine acetate does not impair the metabolism of three model substrates used to assess hepatic drug clearance.
Authors:
E Tanaka; K Nakamura
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  28     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-23     Completed Date:  1989-10-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
Affiliation:
Institute of Community Medicine, University of Tsukuba, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipyrine / pharmacokinetics,  urine
Cimetidine / pharmacology*
Half-Life
Histamine H2 Antagonists / pharmacology*
Humans
Indocyanine Green / pharmacokinetics
Liver / drug effects,  metabolism*
Male
Pharmaceutical Preparations / metabolism*
Piperidines / pharmacology*
Trimethadione / pharmacokinetics
Chemical
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Pharmaceutical Preparations; 0/Piperidines; 127-48-0/Trimethadione; 3599-32-4/Indocyanine Green; 51481-61-9/Cimetidine; 60-80-0/Antipyrine; 78628-28-1/roxatidine acetate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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