| The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous administration of three model substrates. | |
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MedLine Citation:
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PMID: 2570603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of pretreatment for 7 days with either roxatidine acetate 75 mg twice daily or cimetidine 200 mg four times daily on the kinetics of antipyrine (AP), trimethadione (TMO) and indocyanine green (ICG) was studied in seven healthy, male, nonsmoking subjects. After pretreatment with cimetidine, the plasma clearances (CL) of AP and TMO were significantly lower and the elimination half-life (t1/2) of AP was significantly increased. The volumes of distribution (V) of AP and TMO were not affected. After roxatidine acetate, the pharmacokinetics of AP and TMO were unchanged. The cumulative renal excretion (% dose) and formation clearance of 3-hydroxymethyl-3-nor-antipyrine (NORA) were lowered by cimetidine treatment, but not following the administration of roxatidine acetate. ICG clearance was not changed significantly by either pretreatment. The results of this study show that roxatidine acetate does not impair the metabolism of three model substrates used to assess hepatic drug clearance. |
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Authors:
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E Tanaka; K Nakamura |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 28 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-10-23 Completed Date: 1989-10-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 171-4 Citation Subset: IM |
Affiliation:
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Institute of Community Medicine, University of Tsukuba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipyrine / pharmacokinetics, urine Cimetidine / pharmacology* Half-Life Histamine H2 Antagonists / pharmacology* Humans Indocyanine Green / pharmacokinetics Liver / drug effects, metabolism* Male Pharmaceutical Preparations / metabolism* Piperidines / pharmacology* Trimethadione / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Pharmaceutical Preparations; 0/Piperidines; 127-48-0/Trimethadione; 3599-32-4/Indocyanine Green; 51481-61-9/Cimetidine; 60-80-0/Antipyrine; 78628-28-1/roxatidine acetate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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