Document Detail

The effect of riboflavin-ultraviolet A-induced collagen cross-linking on intraocular pressure measurement: an experimental study.
MedLine Citation:
PMID:  22467939     Owner:  NLM     Status:  Publisher    
PURPOSE: To investigate the effect of corneal collagen cross-linking (CCL) on tonopen measurements of intraocular pressure (IOP). METHODS: CCL with 0.1% riboflavin solution and 30 min of ultraviolet A radiation was performed on the right eye of 15 New Zealand albino adult rabbits (1.8-2.4 kg) (15 eyes). The left eye served as control. IOP was measured by a pressure transducer system (true IOP) and by the tonopen hand-held device (corneal applanation tonometer) before treatment, at 1 week, 1 month and 3 months following CCL. Reference pressure in the globe was increased by increments of 10 mm Hg from 10 to 40 mm Hg, using an anterior chamber infusion on a stand with variable height, and tonopen IOP measurements were recorded for each reference pressure in both eyes. RESULTS: Before CCL, tonopen readings were similar between the two eyes (p>0.05). Tonopen underestimated the true IOP in all cases. Following CCL treatment, IOP measurements were significantly higher in the treated eye, at all time intervals (0.005<p<0.03). The most significant difference between true and measured IOP was noted at a reference pressure of 20 mm Hg. CONCLUSIONS: IOP measurements following CCL are overestimated by the tonopen, probably due to increased stiffness of the treated cornea.
Eitan Livny; Igor Kaiserman; Naama Hammel; Tami Livnat; David Zadok; Kremer Israel; Irit Bahar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-30
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  -     ISSN:  1468-2079     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Rabin Medical Center, Petah-Tiqva, Israel.
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