Document Detail


The effect of rheumatoid factor on the clearance of endogenous immune complexes formed in low-affinity mice during the induction of immune complex disease.
MedLine Citation:
PMID:  2953686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous injection of rheumatoid factor (RF) had a marked effect on the clearance kinetics of immune complexes (IC) formed in vivo during induction of chronic immune complex disease in low-affinity mice. RF resulted in a significant increase in IC level and clearance time in 64% of mice with circulating IC after antigen injection, suggesting that RF may alter the handling of potentially pathogenic IC which localize in the renal capillaries causing glomerulonephritis.
Authors:
M E Devey; D N Hogben
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  83     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-07-15     Completed Date:  1987-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  206-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Affinity
Antigen-Antibody Complex / immunology*
Immune Complex Diseases / immunology*
Metabolic Clearance Rate
Mice
Rheumatoid Factor / immunology*
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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