Document Detail

The effect of Rh-negative disease on perinatal mortality: some evidence from the Skellefteå region, Sweden, 1860-1900.
MedLine Citation:
PMID:  23137077     Owner:  NLM     Status:  MEDLINE    
The Rh-negative gene is a well-known cause of perinatal mortality. In this article, we analyze the possible role of Rh disease in perinatal mortality and stillbirths in a particular historical setting: the Skellefteå region in northern Sweden between 1860 and 1900. The data used for the study cover 23,067 children born to 4,943 women. The exact impact is not possible to establish using historical data, but the typical pattern of the disease allows us to make estimations. The expected levels based on knowledge of blood group distribution, the risk of sensitization from Rh incompatability, and the risk of perinatal mortality in births by sensitized mothers are compared with the observed levels. The results show that Rh disease was important for perinatal mortality and clustering of deaths within families.
Erling Häggström Lundevaller; Sören Edvinsson
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Biodemography and social biology     Volume:  58     ISSN:  1948-5565     ISO Abbreviation:  Biodemography Soc Biol     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-09     Completed Date:  2013-03-05     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101500303     Medline TA:  Biodemography Soc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-32     Citation Subset:  IM    
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MeSH Terms
Cluster Analysis
Demography / history*,  statistics & numerical data
Family / history*
Hematologic Diseases / history*,  mortality
History, 19th Century
Perinatal Mortality / history*
Rh-Hr Blood-Group System / genetics,  history
Risk Factors
Stillbirth / epidemiology*
Sweden / epidemiology
Reg. No./Substance:
0/Rh-Hr Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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