| The effect of retinoids on premalignant oral lesions: focus on topical therapy. | |
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MedLine Citation:
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PMID: 12216093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Retinoids have been studied as chemopreventive treatment for patients with oropharyngeal carcinoma. Vitamin A modulates growth and differentiation of cells, and its deficiency enhances susceptibility to carcinogenesis. The chemopreventive mechanism of action of vitamin A is discussed, and a review of clinical results and side effects of the systemic use of vitamin A is included. The objective of the current report was to review the possible role of topical vitamin A and vitamin A derivatives in the management of patients with oral lesions with a risk of transformation to carcinoma. METHODS: A Medline search was conducted and references identified within the identified papers were also reviewed. RESULTS: Only four studies using topical vitamin A for patients with oral leukoplakia have been reported. A complete response was achieved in 10-27% of patients, and a partial response was achieved in 54-90% of patients; however, recurrence of leukoplakia was reported after withdrawing the medication in approximately 50% of patients. The side effects of the topical use were minimal. CONCLUSIONS: Although the direct application of higher concentrations of retinoic acid results in suppression of oral leukoplakias only, its use in the treatment of patients with recurrent and persistent lesions may be justified for controlling lesions that otherwise may progress. Further controlled clinical studies are needed. |
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Authors:
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Meir Gorsky; Joel B Epstein |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cancer Volume: 95 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-06 Completed Date: 2002-09-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1258-64 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2002 American Cancer Society. |
Affiliation:
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The Maruice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Humans Leukoplakia, Oral / drug therapy* Precancerous Conditions / drug therapy* Retinoids / administration & dosage* Vitamin A / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Retinoids; 11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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