Document Detail

The effect of remifentanil on the emergence characteristics of children undergoing FBO for bronchoalveolar lavage with sevoflurane anaesthesia.
MedLine Citation:
PMID:  19401665     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: The aim of this study was to compare the effects of sevoflurane vs. sevoflurane and remifentanil on cough and agitation during emergence and recovery after fiberoptic bronchoscopy. METHODS: Children between 2 and 6 years of age undergoing fiberoptic bronchoscopy were enrolled. All patients were premedicated with oral midazolam. Patients were randomly assigned to either group S (sevoflurane alone, n = 25) or group SR (sevoflurane with remifetanil, n = 25). Anaesthesia was induced and maintained with sevoflurane in all patients. Group SR received remifentanil at a bolus dose of 1 microg/kg over 2 min followed by a maintenance infusion of 0.15 microg/kg/min. In addition to routine anaesthesia documentation, agitation scores and cough scores were recorded every 5 min during emergence and recovery. RESULTS: Duration of the procedure, anaesthesia and emergence phases was similar in both groups (P > 0.05). Time until recovery was significantly shorter in group SR than in group S (7.0 +/- 5.5 min and 13.0 +/- 3.5 min, respectively; P = 0.001). Cough scores were not significantly different between the two groups during emergence and recovery (Kruskal-Wallis ANOVA test, P > 0.05). However, the mean agitation score at 5 min in group SR was significantly higher than that in group S (Kruskal-Wallis ANOVA test, P < 0.01). One case of hypoxaemia from thoracic rigidity occurred in a patient in group SR. CONCLUSION: The addition of remifentanil significantly shortened recovery time in children undergoing fiberoptic bronchoscopy under sevoflurane anaesthesia. In the recovery period, remifentanil did not decrease cough, and increased agitation.
Tulun Ozturk; Koray Erbuyun; Gonul Tezcan Keles; Mert Ozer; Hasan Yuksel; Demet Tok
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  26     ISSN:  1365-2346     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-29     Completed Date:  2009-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-42     Citation Subset:  IM    
Department of Anaesthesiology and Reanimation, Celal Bayar University School of Medicine, Manisa, Turkey.
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MeSH Terms
Analgesics, Opioid / pharmacology*
Anesthesia Recovery Period*
Anesthetics, Inhalation
Bronchoalveolar Lavage / instrumentation,  methods
Bronchoscopy / adverse effects
Child, Preschool
Cough / etiology,  prevention & control*
Fiber Optic Technology
Methyl Ethers
Piperidines / pharmacology*
Psychomotor Agitation / etiology,  prevention & control*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Inhalation; 0/Methyl Ethers; 0/Piperidines; 132875-61-7/remifentanil; 28523-86-6/sevoflurane

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