| The effect of red blood cell age on coagulation. | |
| | |
MedLine Citation:
|
PMID: 19969149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Packed red blood cell (PRBC) units stored and unused at community hospitals are transferred to trauma centers near the end of their shelf storage life, because of a higher likelihood of utilization before expiration without consideration of coagulation system effects. This study was conducted to determine if the stored age of PRBC units has an effect on coagulation. METHODS: Single-donor citrate/phosphate/dextrose-preserved, PRBCs, and fresh frozen plasma (FFP) were recalcified in an in vitro model. The activated clotting time (ACT) was measured using the microsample method on days 3, 19, 20, and 33 from the date of donation. RESULTS: The ACT was prolonged as the age of PRBCs increased while other factors were held constant. ACTs on days 19, 20, and 33 were prolonged relative to day 3. Measurements taken on day 33 were significantly prolonged relative to day 20. CONCLUSIONS: Increasing age of PRBCs measured from the date of donation adversely affects the global coagulation status. This study suggests that we should re-evaluate current blood banking and transfusion practices in trauma care. |
| | |
Authors:
|
John A Aucar; Edan Isaak; Douglas Anthony |
Related Documents
:
|
18291279 - An evaluation of guttaflow and gutta-percha in the filling of lateral grooves and depre... 18684259 - Right pectoral implantable cardioverter defibrillators: role of the proximal (svc) coil. 2858289 - Circannual changes in blood coagulation factors and the effect of warfarin on the hedge... 6721249 - Microvascular alterations in thrombin-induced experimental disseminated intravascular c... 8794429 - Effects of progestogens on haemostasis. 1472589 - In vitro rheological evaluation of antithrombogenicity or anticoagulability of styrene ... 12115239 - Increased urinary f2-isoprostanes in systemic sclerosis, but not in primary raynaud's p... 4062359 - Pulmonary and neurobehavioral effects of formaldehyde exposure. 3941319 - Changes in regional blood-brain transfer of l-leucine elicited by arginine-vasopressin. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of surgery Volume: 198 ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-08 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 900-4 Citation Subset: AIM; IM |
Affiliation:
|
University of Illinois Urbana-Champaign/Carle Foundation Hospital, Urbana, IL, USA. john.aucar@carle.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Coagulation* Blood Preservation / standards*, statistics & numerical data* Erythrocytes* Humans Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Complications of recombinant activated human coagulation factor VII.
Next Document: Initial experiences and outcomes of telepresence in the management of trauma and emergency surgical ...