Document Detail

The effect of recombinant human soluble thrombomodulin on disseminated intravascular coagulation in an abdominal aortic aneurysm.
MedLine Citation:
PMID:  24378974     Owner:  NLM     Status:  Publisher    
Aortic aneurysms are sometimes accompanied with disseminated intravascular coagulation (DIC). The definitive treatment of DIC is removal of underlying disease; surgical repair for the aortic aneurysms. Heparin, anticoagulant and other antifibrinolytic agents have been administered preoperatively to alleviate DIC whose bleeding tendency could cause high mortality and morbidity; however, their effectiveness was indeterminate. An 84-year-old man was presented with abdominal aortic aneurysm accompanied by DIC and underwent aneurysmectomy. After having confirmed that combined use of heparin and gabexate mesilate was ineffective, we used recombinant human soluble thrombomodulin (rhsTM), which has been reported to be more effective and safer than the heparin, for a week preoperatively, and demonstrated dramatic improvement of DIC. RhsTM should be a novel powerful therapeutic option for aneurysm-induced DIC.
Katsuyuki Hoshina; Kunihiro Shigematsu; Akihiro Hosaka; Hiroyuki Okamoto; Tetsuro Miyata; Toshiaki Watanabe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-27
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  -     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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