| The effect of recombinant alpha-interferon on natural killer cell activity and clinical course in patients with myelodysplastic syndrome. | |
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MedLine Citation:
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PMID: 1830225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirteen patients with myelodysplastic syndrome (MDS) were included in this study and consented to treatment with recombinant alpha-interferon (a-IFN). These patients were subclassified: six as RAEB, one as RAEB-T and six as CMML. T-cell subsets and natural killer cells were identified in the peripheral blood with the use of monoclonal antibodies and natural killer cell activity (NKa) was assayed before, during and after a-INF treatment. The treatment schedule consisted of 2.0 MU/m2 sc t.i.w. continuously for the three months. Prior to treatment, NKa was found decreased in 11 of 13 patients as compared to that of normal individuals. Following a-IFN administration, a rise of NKa was observed in eight of the eleven patients. In those who responded, a-IFN was continued for 1 to 21 months. Alpha-IFN treatment was myelosuppressive for most of the patients, but transient increase of the number of neutrophils and platelets was observed in 3 and of the reticulocytes in one patient. Disease progression was recorded in 9/13 patients (69%) at a median time of 17.3 months. The median overall survival was 30.5 months (range 7.5 to 65+ months). No evidence of a relationship was found between the rise in Nka and the limited clinical improvement observed. Two NKa responders under continuous a-IFN treatment are in stable clinical condition for 36+ and 65+ months. The study provides only limited evidence that a-IFN may improve the clinical course of patients with MDS. |
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Authors:
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X Yataganas; G Eliopoulos; S Koulocheri; N Viniou; E Plata; P Panagiotidis; G Vayopoulos; J Meletis; P Fessas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of hematology Volume: 62 ISSN: 0939-5555 ISO Abbreviation: Ann. Hematol. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-08-27 Completed Date: 1991-08-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, University of Athens Medical School, Laiko Hospital, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, CD3 Antigens, CD4 / analysis Antigens, CD8 Antigens, Differentiation, T-Lymphocyte / analysis Female Humans Interferon Type I / pharmacology* Killer Cells, Natural / drug effects, physiology* Leukemia / etiology Male Middle Aged Myelodysplastic Syndromes / drug therapy* Receptors, Antigen, T-Cell / analysis Recombinant Proteins / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD3; 0/Antigens, CD4; 0/Antigens, CD8; 0/Antigens, Differentiation, T-Lymphocyte; 0/Interferon Type I; 0/Receptors, Antigen, T-Cell; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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