Document Detail

The effect of raising or lowering tryptophan levels on aggression in vervet monkeys.
MedLine Citation:
PMID:  3432316     Owner:  NLM     Status:  MEDLINE    
Social groups of vervet monkeys (Cercopithecus aethiops) were given amino acid mixtures that were tryptophan-free (T-), nutritionally balanced (B), or contained excess tryptophan (T+). The T- mixture caused a marked decrease in plasma tryptophan and the T+ mixture a large increase. Behavioral observations were made on the animals after administration of the amino acid mixtures both during spontaneous activity and while the (fasted) animals were competing for food newly placed in the feeder. The only effect of the biochemical manipulations on spontaneous aggression was an increase in aggression of the male animals with the T- mixture. During competition for the food the T- mixture increased and the T+ mixture decreased aggression in the males, while the T+ mixture decreased aggression in females. These data indicate that brain 5-hydroxytryptamine can influence aggression in a primate and suggest that altered tryptophan levels can influence aggression more reliably at higher levels of arousal.
B Chamberlain; F R Ervin; R O Pihl; S N Young
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  28     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-03-10     Completed Date:  1988-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-10     Citation Subset:  IM    
Department of Psychology, McGill University, Montreal, Canada.
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MeSH Terms
Aggression / drug effects*
Cercopithecus aethiops
Grooming / drug effects
Motor Activity / drug effects
Sex Factors
Sexual Behavior, Animal / drug effects
Social Behavior
Tryptophan / blood,  deficiency,  pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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