Document Detail


The effect of radiofrequency radiation on DNA and lipid damage in female and male infant rabbits.
MedLine Citation:
PMID:  22145622     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Purpose: We aimed to design a prolonged Radiofrequency (RF) radiation exposure and investigate in an animal model, possible bio-effects of RF radiation on the ongoing developmental stages of children from conception to childhood. Materials and methods: A total of 72 New Zealand female and male white rabbits aged 1-month were used. Females were exposed to RF radiation for 15 min/day during 7 days, whereas males were exposed to the same level of radiation for 15 min/day during 14 days. Thirty-six female and thirty-six male infant rabbits were randomly divided into four groups: Group I [Intrauterine (IU) exposure (-); Extrauterine (EU) exposure (-)]: Sham exposure which means rabbits were exposed to 1800 MHz Global System for Mobile Telecommunication (GSM)-like RF signals neither in the IU nor in the EU periods. Group II [IU exposure (-); EU exposure (+)]: Infant rabbits were exposed to 1800 MHz GSM-like RF signals when they reached 1-month of age. Group III [IU exposure(+); EU exposure (-)]: Infant rabbits were exposed to 1800 MHz GSM-like RF signals in the IU period (between 15(th) and 22(nd) days of the gestational period). Group IV [IU exposure(+); EU exposure (+)]: Infant rabbits were exposed to 1800 MHz GSM-like RF signals both in the IU period (between 15(th) and 22(nd) days of the gestational period) and in the EU period when they reached 1-month of age. Biochemical analysis for lipid peroxidation and DNA damage were carried out in the livers of all rabbits. Results: Lipid peroxidation levels in the liver tissues of female and male infant rabbits increased under RF radiation exposure. Liver 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels of female rabbits exposed to RF radiation were also found to increase when compared with the levels of non-exposed infants. However, there were no changes in liver 8-OHdG levels of male rabbits under RF exposure. Conclusion: Consequently, it can be concluded that GSM-like RF radiation may induce biochemical changes by increasing free radical attacks to structural biomolecules in the rabbit as an experimental animal model.
Authors:
Goknur Guler; Arin Tomruk; Elcin Ozgur; Duygu Sahin; Aylin Sepici; Nilgun Altan; Nesrin Seyhan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-7
Journal Detail:
Title:  International journal of radiation biology     Volume:  -     ISSN:  1362-3095     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enantioselective bromocycloetherification by Lewis base/chiral Brønsted acid cooperative catalysis.
Next Document:  Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophi...