Document Detail

The effect of pulsatile perfusion on cerebral blood flow during profound hypothermia with total circulatory arrest.
MedLine Citation:
PMID:  8028354     Owner:  NLM     Status:  MEDLINE    
In 39 mongrel dogs, regional cerebral blood flow was measured during pulsatile and nonpulsatile deep hypothermic cardiopulmonary bypass with total circulatory arrest. Total circulatory arrest was performed at 20 degrees C cerebral temperature for 40 minutes in 15 dogs, 60 minutes in 12 dogs, and 80 minutes in 12 dogs. Cerebral blood flow in both groups decreased as cerebral temperature fell and there was no significant difference in cerebral blood flow between the two groups during the cooling period. After circulatory arrest for 40 minutes, as cerebral temperature increased to 35 degrees C, cerebral blood flow in both groups recovered to values as high as the respective initial values, which were measured just after the beginning of cardiopulmonary bypass for cooling (102.5% +/- 10.2% in the pulsatile group and 97.2% +/- 12.6% in the nonpulsatile group). After circulatory arrest for 60 minutes, cerebral blood flow in the pulsatile group increased to 141.8% +/- 16.1% of its initial value when the cerebral temperature became 35 degrees C, but it remained significantly lower (64.5% +/- 9.2%) in the nonpulsatile group (p < 0.01). After circulatory arrest for 80 minutes, cerebral blood flow in both groups remained lower than the respective initial values. These results suggest that pulsatile perfusion maintains cerebral blood flow even during profound hypothermia and that it may protect the brain from ischemic and hypoxic damage caused by profound hypothermia and total circulatory arrest in cardiac operations.
M Onoe; A Mori; S Watarida; T Sugita; S Shiraishi; T Nojima; Y Nakajima; R Tabata; S Matsuno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  108     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-08-09     Completed Date:  1994-08-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  AIM; IM    
Second Department of Surgery and Emergency Medicine, Shiga University of Medical Science, Japan.
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MeSH Terms
Blood Flow Velocity
Cardiopulmonary Bypass*
Cerebrovascular Circulation*
Heart Arrest, Induced*
Hypothermia, Induced*
Pulsatile Flow*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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