| The effect of a protein meal on zidovudine pharmacokinetics in HIV-infected patients. | |
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MedLine Citation:
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PMID: 1389940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eleven HIV-infected men participated in a randomized, two-treatment, two-period crossover study to determine the effect of a 25 g protein meal on zidovudine pharmacokinetics. On two separate occasions, 1 week apart, each patient received 200 mg zidovudine in a fasting state or immediately following the protein meal. A protein meal significantly decreased Cmax [532 (228 s.d.) vs 802 (452 s.d.) ng ml-1, P = 0.004] and increased mean residence time (138 (26 s.d.) vs 114 (26 s.d.) min, corrected for lag times, P = 0.001). However, AUC, tmax, terminal half-life and renal clearance were not significantly altered (P greater than 0.05). The power to detect a 20% change in AUC was 98% at the 5% significance level. In contrast to fat-containing foods, protein-based meals may not alter the extent of zidovudine absorption. |
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Authors:
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J Sahai; K Gallicano; G Garber; I McGilveray; N Hawley-Foss; N Turgeon; D W Cameron |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 33 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 657-60 Citation Subset: IM; X |
Affiliation:
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Department of Medicine, Ottawa General Hospital, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dietary Proteins
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administration & dosage* HIV Infections / metabolism* Half-Life Humans Kidney / physiopathology Male Zidovudine / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 30516-87-1/Zidovudine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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