Document Detail


The effect of protease inhibitors derived from potato formulated in a minidrink on appetite, food intake and plasma cholecystokinin levels in humans.
MedLine Citation:
PMID:  20644555     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background:Protease inhibitor 2 derived from potato (PI2) is claimed to reduce appetite and food intake, stimulate the satiety hormone cholecystokinin (CCK) and lower postprandial glucose peaks when taken before a meal. However, current literature is inconclusive with regard to its efficacy and mechanism. Furthermore, the potential effect of PI2 on appetite motivational ratings without an immediately following meal has not previously been reported.Objective:To comprehensively test the effects of 30 mg PI2 in a minidrink on appetite ratings, subsequent food intake, and plasma CCK and glucose responses.Design:Minidrinks with or without 30 mg PI2 were compared in three separate substudies (A, B and C), each using a two-way, placebo-controlled, balanced-order, cross-over design and 23 or 24 subjects (mean over groups: body mass index 25.0 kg m(-2), range 22.5-30.7 kg m(-2); age 41.3, range 18-62 years). The minidrink was given (A) 120 or (B) 30 min before an ad libitum lunch or (C) 30 min before a fixed lunch. Study parameters were self-reported satiety (substudies A and C), ad libitum meal intake (substudies A and B), and (in an n=12 subset) plasma CCK and blood glucose in all substudies. All results were analyzed using analysis of covariance. Protease-inhibitory activity of the PI2-containing minidrinks was assessed under simulated gut conditions.Results:PI2 did not differ from control for any study parameters, in any substudy, despite confirmation of the inhibitory activity of PI2.Conclusions:In this study protease inhibition using PI2 in a minidrink at a dose of 30 mg, as commercially used, had no (functional) efficacy on a range of behavioral and physiological appetite and intake control measures.
Authors:
H P F Peters; M Foltz; E M R Kovacs; D J Mela; E A H Schuring; S A Wiseman
Related Documents :
16249445 - Peptide yy(3-36) inhibits morning, but not evening, food intake and decreases body weig...
404865 - Cholecystokinin and satiety in rats and rhesus monkeys.
8971925 - Effects of cholecystokinin octapeptide (cck-8) on food intake in adult and aged rats un...
8185155 - Integration of postprandial function in the proximal gastrointestinal tract. role of cc...
17490715 - Approaches to assess the oral bioaccessibility of persistent organic pollutants: a crit...
15304495 - A plasmodium falciparum dipeptidyl aminopeptidase i participates in vacuolar hemoglobin...
Publication Detail:
Type:  Journal Article     Date:  2010-07-20
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  35     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Affiliation:
Unilever Research & Development, Vlaardingen, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diet vs exercise for the prevention of pediatric obesity: the role of exercise.
Next Document:  Differences emerge in visceral adipose tissue accumulation after selection for innate cardiovascular...