Document Detail

The effect of protamine on serum levels of placental protein 5 (PP5) in normal and abnormal pregnancy: a possible relation to coagulation abnormalities.
MedLine Citation:
PMID:  7225294     Owner:  NLM     Status:  MEDLINE    
The levels of placental protein 5 (PP5) in pregnancy serum show an apparent increase after the addition of protamine sulphate. The difference of the apparent concentrations of serum PP5 in the presence and absence of protamine (delta PP5) was determined in 345 normal and abnormal pregnancies. A positive delta PP5 was less frequent in diabetic pregnancy (45 per cent) and pre-eclampsia (57 per cent) than in normal pregnancy (80 per cent). These findings provide further evidence that PP5 may be involved in the coagulation system, and in particular may relate to abnormal coagulation processes at the placental site.
H T Salem; M Seppälä; T Ranta; H Bohn; T Chard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  88     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-07-23     Completed Date:  1981-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Coagulation
Pre-Eclampsia / blood
Pregnancy / drug effects*
Pregnancy Complications / blood*
Pregnancy Complications, Hematologic / blood
Pregnancy Proteins / blood*
Pregnancy in Diabetics / blood
Protamines / pharmacology*
Reg. No./Substance:
0/Glycoproteins; 0/Pregnancy Proteins; 0/Protamines; 0/tissue-factor-pathway inhibitor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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