Document Detail


The effect of prostaglandins on sulphate and thymidine incorporation in pig cartilage.
MedLine Citation:
PMID:  7394056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prostaglandins A1, A2, B2, E2, and F2 alpha inhibit glycosaminoglycan sulphation in pig costal cartilage discs above 0.1 micrometer M (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 microgram/ml (0.02 mM) prostaglandin E2 and F2 alpha inhibited cartilage DNA synthesis. However at 100 ng/ml (10 microM) this inhibition was again observed. The basal production of prostaglandins E2 and F2 alpha by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.
Authors:
J Falconer; S Dekel; M J Francis
Related Documents :
9171296 - Increased production of interleukin-1beta and interleukin-1 receptor antagonist by peri...
1278116 - Effect of sexual maturation and androgens on prostaglandin levels in tissues of the mal...
16459166 - The antitumor thioredoxin-1 inhibitor px-12 (1-methylpropyl 2-imidazolyl disulfide) dec...
1737726 - In-vivo and in-vitro studies on the effect of amphotericin b on endothelin release.
22323766 - Serum 25-hydroxyvitamin d concentrations and prevalence estimates of hypovitaminosis d ...
16413936 - Determination of some enzymes and macro- and microelements in stallion seminal plasma a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins and medicine     Volume:  4     ISSN:  0161-4630     ISO Abbreviation:  Prostaglandins Med     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7810330     Medline TA:  Prostaglandins Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cartilage / drug effects,  metabolism*
DNA / biosynthesis*
Dose-Response Relationship, Drug
Glycosaminoglycans / biosynthesis*
Prostaglandins / pharmacology*
Prostaglandins A / pharmacology
Prostaglandins B / pharmacology
Prostaglandins E / pharmacology
Prostaglandins F / pharmacology
Sulfates / metabolism*
Swine
Thymidine / metabolism*
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 0/Prostaglandins; 0/Prostaglandins A; 0/Prostaglandins B; 0/Prostaglandins E; 0/Prostaglandins F; 0/Sulfates; 50-89-5/Thymidine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reduction of ferric heme to ferrous by lipid peroxides: possible relevance to the role of peroxide t...
Next Document:  Distribution of prostaglandin F1 alpha in the pregnant rat.