Document Detail

The effect of prostaglandins on sulphate and thymidine incorporation in pig cartilage.
MedLine Citation:
PMID:  7394056     Owner:  NLM     Status:  MEDLINE    
Prostaglandins A1, A2, B2, E2, and F2 alpha inhibit glycosaminoglycan sulphation in pig costal cartilage discs above 0.1 micrometer M (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 microgram/ml (0.02 mM) prostaglandin E2 and F2 alpha inhibited cartilage DNA synthesis. However at 100 ng/ml (10 microM) this inhibition was again observed. The basal production of prostaglandins E2 and F2 alpha by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.
J Falconer; S Dekel; M J Francis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins and medicine     Volume:  4     ISSN:  0161-4630     ISO Abbreviation:  Prostaglandins Med     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7810330     Medline TA:  Prostaglandins Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
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MeSH Terms
Cartilage / drug effects,  metabolism*
DNA / biosynthesis*
Dose-Response Relationship, Drug
Glycosaminoglycans / biosynthesis*
Prostaglandins / pharmacology*
Prostaglandins A / pharmacology
Prostaglandins B / pharmacology
Prostaglandins E / pharmacology
Prostaglandins F / pharmacology
Sulfates / metabolism*
Thymidine / metabolism*
Reg. No./Substance:
0/Glycosaminoglycans; 0/Prostaglandins; 0/Prostaglandins A; 0/Prostaglandins B; 0/Prostaglandins E; 0/Prostaglandins F; 0/Sulfates; 50-89-5/Thymidine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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