Document Detail

The effect of propranolol, verapamil and dantrolene treatment on cardiac hypertrophy, enhanced myocardial contractility and tachycardia in the hyperthyroid rat.
MedLine Citation:
PMID:  2142279     Owner:  NLM     Status:  MEDLINE    
Experimentally induced hyperthyroidism is associated with cardiac hypertrophy, tachycardia and elevated myocardial contractility. To investigate the possibility of ameliorating the cardiac changes pharmacologically, hyperthyroid rats were treated with propranolol, verapamil or dantrolene. Cardiac hypertrophy was assessed from the heart mass: body mass ratio and cardiac function was measured in vitro. Both verapamil and propranolol reversed the cardiac hypertrophy of the hyperthyroid animals from 0.92 +/- 0.02 mg.g-1 to 0.70 +/- 0.01 mg.g-1 (P less than 0.001) and 0.72 +/- 0.02 mg.g-1 (P less than 0.001) respectively. Verapamil was effective in reducing the spontaneous heart rate from 331 +/- 8 beats.min-1 to 273 +/- 7 beats.min-1 (P less than 0.001) while propranolol reduced the dP/dtmax of the hyperthyroid hearts from 4089 +/- 87 mmHg.s-1 to 3497 +/- 97 mmHg.s-1 (P less than 0.001). Dantrolene had no effect on any parameter. We conclude from our results that cardiac hypertrophy of the hyperthyroid heart can be reversed by treatment with propranolol and verapamil probably via their inotropic and chronotropic properties.
A M Wheatley; N Butkow; J Grote; J Musiker; C Rosendorff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  22     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:    1990 May-Jun
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  307-18     Citation Subset:  IM    
Department of Physiology, Univesity of the Witwatersrand Medical School, Johannesburg, South Africa.
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MeSH Terms
Blood Pressure / drug effects
Cardiomegaly / drug therapy*
Coronary Vessels / drug effects,  physiology
Dantrolene / pharmacology*
Euthyroid Sick Syndromes / physiopathology
Heart / anatomy & histology
Heart Rate / drug effects
Hyperthyroidism / physiopathology*
Myocardial Contraction / drug effects*
Organ Size / drug effects
Propranolol / pharmacology*
Rats, Inbred Strains
Systole / drug effects
Tachycardia / drug therapy*
Thyroxine / pharmacology
Verapamil / pharmacology*
Reg. No./Substance:
52-53-9/Verapamil; 525-66-6/Propranolol; 7261-97-4/Dantrolene; 7488-70-2/Thyroxine

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