Document Detail


The effect of propranolol upon chick embryo cardiogenesis.
MedLine Citation:
PMID:  908457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The teratogenic effects of propranolol HCl on cardiac development were studied in chick embryos of days 3 and 4 of incubation. Propranolol was injected into the yolk sac at doses ranging from 0.05 to 0.6 mg per egg. All the treated and control embryos were examined on day 7. The LD50 for the embryos treated on the 3rd and 4th day was 0.15 and 0.35 mg per embryo, respectively. Cardiac anomalies such as aortic stenosis ventricular septal defects and common truncus arteriosus were observed. Other malformations included atrial septal defects, thin atrial wall and defects of the pulmonic, aortic and atrioventricular valves. The incidence of cardiac anomalies in the controls was very low. Propranolol was observed to slow the heart rate in the experimental embryos. It is suggested that slowing of heart rate at the early stages of heart development caused aberrant bloodstream flow patterns which probably resulted in the genesis of cardiac anomalies. The results of this study indicate that propranolol has teratogenic effects on chick embryo cardiogenesis.
Authors:
S H Gilani; A Silvestri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental cell biology     Volume:  45     ISSN:  0304-3568     ISO Abbreviation:  Exp. Cell Biol.     Publication Date:  1977  
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7701827     Medline TA:  Exp Cell Biol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  158-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*
Animals
Chick Embryo
Dose-Response Relationship, Drug
Heart / embryology
Heart Defects, Congenital / chemically induced*
Heart Rate / drug effects
Lethal Dose 50
Propranolol* / pharmacology,  toxicity
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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