Document Detail

The effect of propranolol on exercise induced tachycardia is determined by plasma concentration and the density of adrenergic receptors on leukocytes.
MedLine Citation:
PMID:  3830254     Owner:  NLM     Status:  MEDLINE    
The chronotropic response to a single oral dose of propranolol in 23 healthy subjects has been related to the plasma propranolol concentration and the density of beta-adrenoceptors on peripheral polymorphonuclear leucocytes. The percentage reduction in exercise-induced tachycardia was significantly correlated with the log plasma propranolol concentration within subjects but not between subjects. Taking the concentration of the active metabolite 4-hydroxypropranolol into account did not improve the interindividual correlation. The reduction in exercise-induced tachycardia was significantly correlated with the maximum binding density of (125I)-hydroxybenzylpindolol on polymorphonuclear leucocyte membrane fragments measured before medication. A response index (% reduction in exercise-induced tachycardia/plasma propranolol concentration) was correlated with the maximum binding density of (125I)-hydroxybenzylpindolol (pre-drug) at 2 h (rs = 0.72), 4 h (rs = 0.84) and 6 h (rs = 0.73) after dosing. The data suggest that interindividual variation in the response to propranolol after a single oral dose is determined by interindividual differences both in plasma propranolol and adrenoceptor density.
K Tawara; E Steiner; C von Bahr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  31     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-05-18     Completed Date:  1987-05-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  667-72     Citation Subset:  IM    
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MeSH Terms
Heart Rate / drug effects*
Leukocytes / drug effects*
Neutrophils / drug effects
Physical Exertion
Pindolol / analogs & derivatives,  diagnostic use
Propranolol / analogs & derivatives,  blood,  pharmacology*
Receptors, Adrenergic / drug effects*
Reg. No./Substance:
0/Receptors, Adrenergic; 10476-53-6/4-hydroxypropranolol; 13523-86-9/Pindolol; 525-66-6/Propranolol; 69925-27-5/hydroxybenzylpindolol

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