Document Detail

The effect of propofol and thiamylal on hypertensive responses to a rapid increase in isoflurane concentration.
MedLine Citation:
PMID:  10396712     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To compare the effects of propofol and thiamylal on the hyperdynamic circulatory response caused by a rapid increase in isoflurane concentration. DESIGN: Prospective, randomized, double-blind study. SETTING: Operating rooms of a university hospital. PATIENTS: 30 ASA physical status I adult patients scheduled for elective surgery with general anesthesia. INTERVENTIONS: Patients were anesthetized with either propofol 2 mg/kg (propofol group, n = 15) or thiamylal 4 mg/kg (thiamylal group, n = 15). Two minutes after anesthesia induction, the inspired isoflurane concentration was rapidly increased from 0.5% to 5% and maintained for 5 minutes. MEASUREMENTS AND MAIN RESULTS: Mean arterial pressure significantly increased after the increase in isoflurane concentration in the thiamylal group, but it did not change in the propofol group. The isoflurane-induced increase in rate-pressure product was significantly greater in the thiamylal group than in the propofol group. CONCLUSION: Propofol induction of anesthesia more effectively attenuates the circulatory responses to a sudden increase in isoflurane concentration than does thiamylal.
M Nakayama; N Kanaya; H Tsuchida; A Namiki
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  11     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-10     Citation Subset:  IM    
Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan.
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MeSH Terms
Analysis of Variance
Anesthetics, Inhalation*
Anesthetics, Intravenous*
Dose-Response Relationship, Drug
Double-Blind Method
Hypertension / drug therapy*
Middle Aged
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 26675-46-7/Isoflurane; 77-27-0/Thiamylal

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