| The effect of propofol and desflurane anaesthesia on human hepatic blood flow: a pilot study. | |
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MedLine Citation:
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PMID: 20860555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study tested the hypothesis that propofol is associated with a higher hepatic blood flow in humans compared with desflurane. Using a cross over study design, 10 patients received first propofol and then desflurane, and a further 10 patients received desflurane and then propofol. Blood flow index in the right and middle hepatic veins, stroke volume index and cardiac index were assessed by transoesophageal echocardiography. Mean arterial blood pressure, stroke volume index and cardiac index were the same in both groups. Propofol was associated with significantly greater blood flow index in the right hepatic vein (median (IQR [range]) 199 (146-237 [66-388]) vs. 149 (112-189 [42-309]) ml.min(-1).m(-2); p = 0.005) and middle hepatic vein (150 (122-191 [57-341]) vs. 125 (92-149 [47-362]) ml.min(-1).m(-2); p < 0.001) compared with desflurane. In routine clinical conditions, propofol anaesthesia was associated with significantly greater hepatic blood flow than desflurane anaesthesia. |
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Authors:
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R Meierhenrich; A Gauss; B Mühling; H Bracht; P Radermacher; M Georgieff; F Wagner |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-09-21 |
Journal Detail:
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Title: Anaesthesia Volume: 65 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 1085-93 Citation Subset: AIM; IM |
Copyright Information:
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© 2010 The Authors. Anaesthesia © 2010 The Association of Anaesthetists of Great Britain and Ireland. |
Affiliation:
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Department of Anaesthesiology, University Clinic Ulm, Ulm, Germany. rainer.meierhenrich@uniklinik-ulm.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anesthetics, Inhalation / pharmacology* Anesthetics, Intravenous / pharmacology* Cross-Over Studies Echocardiography, Transesophageal Female Hemodynamics / drug effects Hepatic Veins / drug effects, physiology, ultrasonography Humans Isoflurane / analogs & derivatives*, pharmacology Liver Circulation / drug effects* Male Middle Aged Pilot Projects Propofol / pharmacology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 26675-46-7/Isoflurane; 57041-67-5/desflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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