Document Detail


The effect of prophylactic metaraminol on systemic hypotension caused by induction of anaesthesia with propofol in patients over 55 years old.
MedLine Citation:
PMID:  11531679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a double-blind, randomised, placebo-controlled study evaluating the efficacy of prophylactic metaraminol for preventing propofol-induced hypotension. Thirty patients aged 55-75 years undergoing general anaesthesia were randomly allocated to receive either metaraminol 0.5 mg or saline before administration of fentanyl 1 microg.kg(-1) and propofol 2 mg.kg(-1). Induction of anaesthesia was associated with a decrease in mean and systolic arterial pressure in both groups (p = 0.0001). However, there was no significant difference between the two groups. These results show that prophylactic use of metaraminol 0.5 mg does not prevent the decrease in blood pressure following fentanyl and propofol induction in older patients.
Authors:
C L Chiu; G P Tew; C Y Wang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  56     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  893-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesia, Faculty of Medicine, University of Malaya, 59100 Kuala Lumpur, Malaysia. chiucl@medicine.med.um.edu.my
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / therapeutic use*
Aged
Anesthesia, General / methods
Anesthetics, Intravenous / adverse effects*
Blood Pressure / drug effects
Double-Blind Method
Female
Heart Rate / drug effects
Humans
Hypotension / chemically induced,  prevention & control*
Male
Metaraminol / therapeutic use*
Middle Aged
Propofol / adverse effects*
Vasoconstrictor Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Intravenous; 0/Vasoconstrictor Agents; 2078-54-8/Propofol; 54-49-9/Metaraminol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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