Document Detail

The effect of prolonged cryopreservation on embryo survival.
MedLine Citation:
PMID:  12396558     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to assess the effects of long-term cryopreservation on the survival and implantation rates of embryos. We performed a matched case-control study comparing 101 women whose embryos were transferred after cryopreservation for 2-9 years, with 101 control women whose embryos were transferred after 6 months or less of cryopreservation. A multiple step-wise logistic regression was performed to determine the independent effect of the duration of cryopreservation, patient age and embryo quality on pregnancy and live birth rates. In the study group, 673 embryos were frozen for 24-108 months and of these 451 were thawed. In the control group, 513 embryos were cryopreserved for up to 6 months and 456 were thawed. The implantation rate was similar (4.5% vs. 5.5%) in both groups. We concluded that the duration of cryopreservation did not adversely affect embryo survival, and prolonged cryopreservation appeared to be a safe treatment option.
R Machtinger; J Dor; J Levron; S Mashiach; D Levran; D S Seidman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  16     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-24     Completed Date:  2002-12-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Tel-Aviv, Israel.
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MeSH Terms
Embryo Implantation
Embryo Transfer
Embryo, Mammalian / physiology*
Fertilization in Vitro
Hot Temperature
Infertility / etiology,  therapy
Logistic Models
Time Factors
Tissue and Organ Harvesting

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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