Document Detail


The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury.
MedLine Citation:
PMID:  2282348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indications for aspirin following percutaneous transluminal angioplasty are not well defined. Although aspirin's early antithrombotic effect is believed to be beneficial, the long-term influence of aspirin on myointimal proliferative response following balloon-catheter angioplasty is still being investigated. This study quantitates arterial wall thickening, including intimal hyperplasia, at 4 months following balloon-catheter aortic injury in New Zealand white rabbits (n = 12), comparing aspirin treatment (30 mg/kg) with controls. Aspirin was administered daily for 1 month prior and 4 months following aortic injury. Myointimal proliferation was noted in both groups. The mean area of the intima and media as well as the maximum thickness of the intima were similar (p greater than .05) in both the aspirin treatment and control groups. Cellular hyperplasia was evaluated by media smooth muscle cell counts using an ocular reticle. There was a trend toward higher cell counts with aspirin treatment, although there was no significant difference between the two groups. Prolonged aspirin therapy did not alter the degree of myointimal hyperplasia at 4 months postinjury in our model.
Authors:
R A Yeager; D R Trune; S Jacobson; R S Connell; W T Galey; R G Shoemake; R M Vetto
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  3     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
Affiliation:
Surgical Service, Veterans Administration Medical Center Portland, OR 97207.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / injuries*,  pathology,  surgery
Aspirin / administration & dosage,  therapeutic use*
Balloon Dilatation / adverse effects*
Hyperplasia
Male
Rabbits
Grant Support
ID/Acronym/Agency:
S07 RR05412/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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